EXPERIMENTAL STUDY ON GROWTH PERFORMANCE AND ANTIOXIDANT DEFENSE IN IRON INDUCED OXIDATIVE STRESS AND EVALUATION OF CERTAIN HERBS AND HERBAL COMBINATION IN BROILERS
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Date
2015-11
Journal Title
Journal ISSN
Volume Title
Publisher
Indian Veterinary Association Kerala
Abstract
Free radicals are continuously produced by the body and are also generated through environ-
mental pollution, radiation, drugs, chemicals, pesticides, etc. Oxidative damage by free radicals can
be prevented by the use of antioxidants such as ascorbic acid, tocopherols, carotenoids and certain
herbs. Of late, several herbs have been reported to counter the peroxidative stress due to several stress-
ors. Keeping the above facts in view, an experimental study Was planned to evaluate the mechanism of
iron-induced oxidative stress and injury to the biological system, and to evaluate the therapeutic po-
tential of certain herbs and herbal combinations against experimental iron toxicosis in broilers. A total
of 90 male broiler chicks (Cobb strain) of day-old age Were randomly divided into 6 groups consisting
of 15 chicks in each group. Group 1 Was maintained as basal diet control and group 2 on ferrous sul-
fate at 0.5% in feed throughout 6 Weeks as iron toxic control Without any treatment. Groups 3-6 Were
maintained on FeSO4 at 0.5% in feed for the 4 Weeks (28 days) of study and thereafter administered
with different herbs and their combinations for the remaining 2 week. The performance parameters
were recorded at weekly intervals. Antioxidant defense profile were estimated at the end of 4th and 6th
Week. Estimation of TBARS and GSH was done at the end of 6th Week. Iron treatment resulted in sig-
nificant (P<0.05) reduction in body Weights, Weekly Weight gain, and GSH (6thWeek), while TBARS
(6th week), SOD, catalase, were significantly (P<0.05) increased at the end of 4th Week in groups 2 to
6 and all these parameters exhibited similar trend at the end of 6th Week in iron toxic control group.
Administration of herbs in groups 3 to 6 caused a marked improvement in all the above parameters
as compared to those of iron toxic control group at the end of 6th Week. Thus, it is concluded that
iron induces biological damage by means of oxidative stress and the herbs/herbal combination in test
offered better amelioration
Description
TNV_KVSC_Y2015_14-15Nov_Pg536-539
Keywords
Veterinary Science