Molecular Diagnosis of Babesia canis Infection with Concurrent of Evans Syndrome in a Labrador Dog
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Date
2019-12
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Abstract
Clinical case is five years old female Labrador dog presented to Small Animal Medicine
unit of TVCC, VCRI, Orathanadu. History is dullness and anorexia two days. Recurrent
tick infestations, anemic and thrombocytopenic crisis were regularly. Vaccination and
deworming were regularly. Physical examination revealed dullness, pale mucosa, vital
parameters were normal and ticks on interdigital space and in ears were noticed. Distended
abdomen, hepatosplenomegaly and petechial hemorrhage on ventral abdomen were
observed. Hematology revealed anemia and thrombocytopenia. Negative for blood born
parasites in peripheral blood smear. Serum biochemical and urine analysis found to be
normal. Serum and EDTA blood were submitted for molecular testing. Flow cytometry
revealed Immune-mediated hemolytic anemia (IMHA) and Immune-mediated
thrombocytopenia (IMTP). MAT negative for leptospira. Babesia canis positive by PCR
method at 394bp. Haematology alteration was studied before and after therapy.
Ultrasonography revealed hepatosplenomegaly. Based on PCR and flow cytometry the
case was confirmed Evans syndrome with Concurrent Babesia canis in a Labrador dog.
Dog treated with Inj. Diminazene aceturate @ 3.5mg/kg IM single dose, Inj. Ringers
lactate @ 100 ml IV, Inj. Ascorbic acid @ 5 ml IV, Inj. Vitamin B complex @ 1ml IV, Inj.
Prednisone @ 0.5mg/ kg IM, Tab. Doxycycline @ 10mg/kg PO and Syrup. Thrombup @
15 ml BID PO. Dog showed clinical improvement as well as hematology parameters.
Description
TNV_IJCMAS_2019_8(12)2522-2526
Keywords
Veterinary Science