Anti-Diabetic Effects of Vanadium Pentoxide And Nano Vanadium Pentoxide in Experimentally Induced Diabetic Rats

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dc.contributor.advisorPandiyan, V.
dc.contributor.advisorLoganathasamy, K.
dc.contributor.advisorSelvasubramanian, S.
dc.contributor.authorVijay, K.
dc.contributor.authorTANUVAS
dc.date.accessioned2017-09-13T07:43:25Z
dc.date.available2017-09-13T07:43:25Z
dc.date.issued2014
dc.description.abstractVanadium is an important trace element that has an insulin mimetic effect and plays an important role in lipid and protein metabolism. The present work was taken up with the objective of studying anti-diabetic and antioxidant activities of vanadium pentoxide and nano vanadium pentoxide on streptozotocin induced diabetic rats. Diabetes was induced in rats by single intraperitoneal injection of streptozotocin at the dose rate of 45 mg/kg body weight. Vanadium pentoxide and nano vanadium pentoxide each at the dose rate of 5 mg/kg body weight were administered orally in normal and diabetic rats for 30 days. The standard oral hypoglycemic agent, glimepiride was used as a reference drug and was administered orally at the dose rate of 800 μg/kg body weight. Both the vanadium pentoxide and nano vanadium pentoxide did not show any toxic effects in normal control rats. It was observed that both the vanadium pentoxide and nano vanadium pentoxide significantly decreased the serum glucose levels, it also significantly decreased the serum triacylglycerol, total cholesterol, urea, creatinine, ALT and AST levels in the blood. Vanadium pentoxide and nano vanadium pentoxide significantly increased the serum protein and liver glycogen levels and also restored the loss of body weight in diabetic rats due to its insulin mimetic effect. No incidence of diarrhoea was observed during the entire experimental period indicating that vanadium did not cause any undesirable adverse effect in gastrointestinal tract. The study also showed that vanadium significantly increased the activities of antioxidant enzymes viz., superoxide dismutase, glutathione peroxidase and catalase. On vanadium treatment, the level of glutathione was increased while the level of lipid peroxidation was decreased. Histopathological studies revealed that vanadium could partially regenerate the β-cells and is non-toxic to liver and kidney tissues. Hence, vanadium with its insulin mimetic action may be used in the form of nanoparticle to produce stable and efficient antidiabetic effect without apparent signs of toxicity. This effect may be attributed to efficient uptake of nanoparticles via gastrointestinal tract due to its smaller size, higher reactivity and biological activity of nanoparticles due to its large surface area to mass ratio and reduced toxicity.en_US
dc.identifier.urihttp://krishikosh.egranth.ac.in/handle/1/5810031001
dc.keywordsVeterinary Science, Veterinary Biochemistry, Streptozotocin, Diabetes, Vanadium, Nanoparticles, Glimepiride, Anti–diabetic and antioxidantsen_US
dc.language.isoen_USen_US
dc.pages01-Apren_US
dc.publisherTANUVAS, Chennaien_US
dc.subAnimal Biochemistryen_US
dc.these.typeM.V.Sc.
dc.titleAnti-Diabetic Effects of Vanadium Pentoxide And Nano Vanadium Pentoxide in Experimentally Induced Diabetic Ratsen_US
dc.typeThesisen_US
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