STUDIES ON MOLECULAR DETECTION AND RISK FACTORS FOR MYCOBACTERIUM SPP., BRUCELLA SPP. AND COXIELLA BURNETII INFECTION IN SMALL RUMINANTS AND IN-CONTACT HUMANS IN CHHATTISGARH

Simple item page
dc.contributor.advisorDr Sanjay Shakya
dc.contributor.authorVIVEK KUMAR NAIK
dc.date.accessioned2024-08-29T09:38:56Z
dc.date.available2024-08-29T09:38:56Z
dc.date.issued2024
dc.description.abstractThe present study was undertaken to explore the zoonotic infections due to Mycobacteria spp., Brucella spp., and Coxiella burnetii. The research aimed to unravel the transmission dynamics of these pathogens between small ruminants and in-contact humans, employing molecular detection methods such as Multiplex PCR for Mycobacteria bovis detection, PCR for Brucella genus identification, AMOS PCR for Brucella species identification, and real-time PCR for Coxiella burnetii detection. The study utilized specific genetic markers, including RD4 and RD1, B4 and B5, AMOS with one reverse primer, and Com1 primer for Mycobacteria spp., Brucella spp., and Coxiella burnetii detection, respectively. Risk factor analysis was conducted using a questionnaire method and SPSS software for univariable and multivariable logistic regression. The study unveiled a 0.75% prevalence of Mycobacteria bovis in small ruminants, with a corresponding herd-level prevalence of 2.6%. Notably, individual animallevel risk factors, encompassing species, age, and sample type, failed to demonstrate statistical significance. Conversely, herd-level risk factors, specifically the number of small ruminants (OR = 1.158, p = 0.003) and the introduction of new animals (OR = 1.090, p = 0.034), were found to be significant. Multivariable logistic regression further revealed that a larger flock size (OR= 1.15, p= 0.004) was significantly associated, emphasizing the complex nature of zoonotic tuberculosis transmission and underscoring the imperative for continuous research to facilitate effective control measures. For Brucella spp., the study disclosed 2.26% prevalence of Brucella melitensis in small ruminants, with variations in species, gender, age, and flock size. Among the 131 small ruminant flocks, 14 flocks were found positive
dc.identifier.urihttps://krishikosh.egranth.ac.in/handle/1/5810214018
dc.language.isoEnglish
dc.subVeterinary Public Health
dc.themeSTUDIES ON MOLECULAR DETECTION AND RISK FACTORS FOR MYCOBACTERIUM SPP., BRUCELLA SPP. AND COXIELLA BURNETII INFECTION IN SMALL RUMINANTS AND IN-CONTACT HUMANS IN CHHATTISGARH
dc.these.typePh.D
dc.titleSTUDIES ON MOLECULAR DETECTION AND RISK FACTORS FOR MYCOBACTERIUM SPP., BRUCELLA SPP. AND COXIELLA BURNETII INFECTION IN SMALL RUMINANTS AND IN-CONTACT HUMANS IN CHHATTISGARH
dc.typeThesis
Files
Original bundle
Now showing 1 - 2 of 2
No Thumbnail Available
Name:
VIVEK THESIS.pdf
Size:
4.17 MB
Format:
Adobe Portable Document Format
Download
No Thumbnail Available
Name:
VIVEK THESIS.pdf
Size:
4.17 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Theses