Experimental Studies on Endotoxic Shock in Goats
Loading...
Date
1991
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Birsa Agricultural University, Ranchi
Abstract
On the basis of the results obtained in this study the followings conclusions were drawn.
1. Induction of endotoxic shock in goats by I/V tion of E. cali Endotoxin (LPS) 100 g kg-1 body weight, is rapid and progressive over a period of 4-12 hours.
2. Despite rise and maintenance of normal body temperature at early and late/terminal shock stages respectively, coldness of the extremities is a consistent feature of preterminal and terminal stages.
3. Significant decline in blood and plasma volumes are suggestive of sequestration of fluid in the body itself in the endotoxic shock in goats.
4. Haemoconcentration does not appear to be a feature of shock in goats despite hypovolemic changes.
5. Magnitude of decline in mean arterial and central venous pressures at the late stages appeared to be the determi nant of the outcome of shook.
6. MAP and CVP can be relied as appropriate indices for delineating the status of shock during progression of this syndrome.
7. Hypodynamic response evidenced by decreased cardiac output, stroke volume, cardiac index and stroke index are the consistent feature of endotoxic shock in goat.