Effect of Concurrent Exposure of Lower Concentrations of Lead and Endosulfan on Hepatic Drug Metabolizing Enzymes in Male Rats

Simple item page
dc.contributor.authorRanganathan, V.
dc.contributor.authorMalik, Jitendra Kumar
dc.contributor.authorBabu, Naraharisetti Suresh
dc.contributor.authorAggarwa, Manoj
dc.contributor.authorRao, G.S.
dc.contributor.authorSankar, P.
dc.contributor.authorTANUVAS
dc.date.accessioned2017-09-04T08:32:13Z
dc.date.available2017-09-04T08:32:13Z
dc.date.issued2016-04
dc.description.abstractThe effect of concurrent repeated exposure of lower concentrations of lead and endosulfan were evaluated on hepatic drug metabolizing enzymes in male rats. Alterations were evaluated through changes in the phase I enzymes (viz. cytochrome P450 and cytochrome b5, aminopyrine N – demethylase and aniline p- hydroxylase) activity and phase II enzymes (viz. microsomal and cytosolic glutathione-S-transferase UDP-glucuronosyl transferase) activity in liver. Lead, when given alone at the dose of 100 ppm in drinking water and endosufan, when given alone at the dose of 10 ppm in feed, and given in combination did not change the activities of cytochrome b5, aminopyrine N – demethylase and aniline phydroxylase. When given in lower dose combination, they significantly inhibited levels of cytochrome 450, microsomal, cytosolic glutathione-S transferase and microsomal protein as compared to control and their single compounds when given alone. This study suggested that activities of xenobiotic drug metabolizing enzymes by repeated exposure to lead and endosulfan at the concentrations used in the study were not modified to produce significant toxicity in case of combined exposure.en_US
dc.identifier.issn2278-3687
dc.identifier.urihttp://krishikosh.egranth.ac.in/handle/1/5810030329
dc.keywordsVeterinary Science, Lead, Endosulfan, Hepatic Drug Metabolizing Enzymesen_US
dc.language.isoen_USen_US
dc.pages788 – 793en_US
dc.relation.ispartofseries;2
dc.subjectVeterinary Scienceen_US
dc.titleEffect of Concurrent Exposure of Lower Concentrations of Lead and Endosulfan on Hepatic Drug Metabolizing Enzymes in Male Ratsen_US
dc.title.alternativeInternational Journal of Science, Environment and Technologyen_US
dc.typeArticleen_US
dc.volume5en_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
TNV_IJSET_Y2016_V05_I02_Pg.788–793.pdf
Size:
62.96 KB
Format:
Adobe Portable Document Format
Description:
TNV_IJSET_Y2016_V05_I02_Pg.788–793
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Articles (1.Journal)