Effect of Concurrent Exposure of Lower Concentrations of Lead and Endosulfan on Hepatic Drug Metabolizing Enzymes in Male Rats
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Date
2016-04
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Abstract
The effect of concurrent repeated exposure of lower concentrations of lead and
endosulfan were evaluated on hepatic drug metabolizing enzymes in male rats. Alterations
were evaluated through changes in the phase I enzymes (viz. cytochrome P450 and
cytochrome b5, aminopyrine N – demethylase and aniline p- hydroxylase) activity and phase
II enzymes (viz. microsomal and cytosolic glutathione-S-transferase UDP-glucuronosyl
transferase) activity in liver. Lead, when given alone at the dose of 100 ppm in drinking water
and endosufan, when given alone at the dose of 10 ppm in feed, and given in combination did
not change the activities of cytochrome b5, aminopyrine N – demethylase and aniline phydroxylase.
When given in lower dose combination, they significantly inhibited levels of
cytochrome 450, microsomal, cytosolic glutathione-S transferase and microsomal protein as
compared to control and their single compounds when given alone.
This study suggested that activities of xenobiotic drug metabolizing enzymes by repeated
exposure to lead and endosulfan at the concentrations used in the study were not modified to
produce significant toxicity in case of combined exposure.
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Veterinary Science