Arsenic reduces the antipyretic activity of paracetamol in rats: Modulation of brain COX-2 activity and CB1 receptor expression

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dc.contributor.authorVijayakaran, Karunakaran
dc.contributor.authorKannan, Kandasamy
dc.contributor.authorKesavan, Manickam
dc.contributor.authorSuresh, Subramaniyam
dc.contributor.authorSankar, Palanisamy
dc.contributor.authorTandan, Surendra Kumar
dc.contributor.authorSarkar, Souvendra Nath
dc.contributor.authorTANUVAS
dc.date.accessioned2018-06-05T10:57:30Z
dc.date.available2018-06-05T10:57:30Z
dc.date.issued2014
dc.descriptionTNV_ETP_2014_37(438-447)en_US
dc.description.abstracttWe examined whether subacute arsenic exposure can reduce paracetamol-mediatedantipyretic activity by affecting COX pathway and cannabinoid CB1receptor regulation.Rats were preexposed to elemental arsenic (4 ppm) as sodium arsenite through drinkingwater for 28 days. Next day pyrexia was induced with lipopolysaccharide and paraceta-mol’s (200 mg/kg, oral) antipyretic activity was assessed. The activities of COX-1 and COX-2,the levels of PGE2, TNF- and IL-1 and expression of CB1receptors were assessed in brain.Arsenic inhibited paracetamol-mediated antipyretic activity. COX-1 activity was not affectedby any treatments. Paracetamol decreased COX-2 activity, levels of PGE2, TNF- and IL-1 andcaused up-regulation of CB1receptors. Arsenic caused opposite effects on these parameters.In the arsenic-preexposed rats, paracetamol-mediated effects were attenuated, while CB1receptor up-regulation was reversed to down-regulation. Results suggest that elevated COX-2 activity and reduced CB1expression could be involved in the arsenic-mediated attenuationof the antipyretic activity of paracetamol.en_US
dc.identifier.urihttp://krishikosh.egranth.ac.in/handle/1/5810049227
dc.keywordsArsenicParacetamolAntipyretic activityCyclooxygenaseCB1 receptorRataen_US
dc.language.isoenen_US
dc.pages438-447en_US
dc.publisherElsevieren_US
dc.subjectVeterinary Scienceen_US
dc.titleArsenic reduces the antipyretic activity of paracetamol in rats: Modulation of brain COX-2 activity and CB1 receptor expressionen_US
dc.title.alternativeEnvironmental Toxicology and Pharmacologyen_US
dc.typeArticleen_US
dc.volume37en_US
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