Arsenic reduces the antipyretic activity of paracetamol in rats: Modulation of brain COX-2 activity and CB1 receptor expression
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Date
2014
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
tWe examined whether subacute arsenic exposure can reduce paracetamol-mediatedantipyretic activity by affecting COX pathway and cannabinoid CB1receptor regulation.Rats were preexposed to elemental arsenic (4 ppm) as sodium arsenite through drinkingwater for 28 days. Next day pyrexia was induced with lipopolysaccharide and paraceta-mol’s (200 mg/kg, oral) antipyretic activity was assessed. The activities of COX-1 and COX-2,the levels of PGE2, TNF- and IL-1 and expression of CB1receptors were assessed in brain.Arsenic inhibited paracetamol-mediated antipyretic activity. COX-1 activity was not affectedby any treatments. Paracetamol decreased COX-2 activity, levels of PGE2, TNF- and IL-1 andcaused up-regulation of CB1receptors. Arsenic caused opposite effects on these parameters.In the arsenic-preexposed rats, paracetamol-mediated effects were attenuated, while CB1receptor up-regulation was reversed to down-regulation. Results suggest that elevated COX-2 activity and reduced CB1expression could be involved in the arsenic-mediated attenuationof the antipyretic activity of paracetamol.
Description
TNV_ETP_2014_37(438-447)
Keywords
Veterinary Science