Identification of Therapeutic Inhibitors for the Treatment of Oral Cancer using Herbal Bio-Active Principles by Means of Computational Approach
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Date
2016
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Abstract
Oral cancer is a type of cancer which targets mouth and
surrounding tissues. It includes, lips, cheeks, tongue, sinuses,throat.
Oral cancer could be life threatening, if not diagnosed in early
stages. American Cancer Society says that men are at more risk
than women. Oral cancer can be treated like any other cancers. But
still the efficacy of the drugs is questionable. Hence, an attempt was
tried to find the suitable inhibitors for the treatment of oral cancer
using bioactive principles of Cissus quadrangularis, targeting
SIRT3,P21 and P53. The Resveratol in Cissus quadrangularis has
showed very good interaction with two target proteins involved in
oral cancer viz., SIRT3 and P21. Resveratol also has very good
pharmacodynamic and pharmacokinetic properties. This study
concludes that Resveratol in Cissus quadrangularis has the
potential to serve as an anticancerous drug. However, the results
might be validated through in-vivo and in-vitro studies to prove the
efficacy of the active compounds and to protect the mankind from
oral cancer.
Description
TNV_AEEICB_2016_1-5
Keywords
Veterinary Science, Bioinformatics