Seminal Plasma Osteopontin: A Marker for Potential Fertility in Dogs
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Date
2021-07
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Abstract
ABSTRACT
Background: Osteopontin (OPN) is an extracellular matrix protein with multifunctions and has been identified in the reproductive
tract of both males and females. OPN from the seminal plasma (SP) has been closely associated with male fertility in several
domestic animals. Different isoforms of OPN has been identified in the SP and sperm membrane in dogs but with unknown functions.
The current study investigated the comparison of key canine sperm microscopic parameters and SP markers between dogs exhibiting
different fertility potential.
Methods: In this investigation during 2018-2019, 21 dogs coming for breeding soundness examination were selected and divided
into fertile (Group I) and hypofertile (Group II). Evaluation included assessment of sperm microscopic characteristics and estimation
of OPN, Malondialdehyde (MDA), Catalase (CAT), Glutathione peroxidase (GPx) and Superoxide dismutase (SOD) concentration in
the SP.
Result: The OPN level showed positive correlation with all the sperm evaluated characteristics (p<0.01). Linear regression analysis
depicted a significant (p<0.001) influence of OPN on the evaluated sperm characteristics. These findings suggest that OPN in the SP
along with the microscopic characteristics of the spermatozoa can be used as a potential fertility marker in discriminating fertile from
the hypofertile ones.
Description
TNV_IJAR_2021_55(7)758-762
Keywords
Veterinary Science