COMPARATIVE EVALUATION OF GUAIFENESIN ADMINISTERED TILETAMINE ZOLAZEPAM AND KETAMINE MIDAZOLAM INDUCTION BOLUSES UNDER ISOFLURANE ANAESTHESIA FOR VARIOUS SURGERIES IN CATTLE
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Date
2022
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KARNATAKA VETERINARY, ANIMAL AND FISHERIES SCIENCES UNIVERSITY, BIDAR – 585 226
Abstract
The study was carried out to evaluate the feasibility of anaesthetic agents using
guaifenesin administered tiletamine-zolazepam and ketamine-midazolam under isoflurane
anaesthesia for various surgeries in cattle. The present study was conducted in 12 clinical
cases of cattle presented to the Department of Veterinary Surgery and Radiology,
Veterinary College, Bidar for the treatment of various surgical affections. The cattle were
randomly divided into two groups consisting of six cattle in each group. The cattle of
group-I were operated under guaifenesin-tiletamine-zolazepam. Guaifenesin was
administered at the dose rate of 50 mg/kg body weight intravenously at 5% solution in
normal saline in the form of drip. After 5 minutes, anaesthesia was induced using
tiletamine-zolazepam bolus given at the dose rate of 3 mg/kg body weight intravenous and
maintained with isoflurane (1-2%). The cattle of group-II were operated under guaifenesinketamine-
midazolam. Guaifenesin was administered at the dose rate of 50 mg/kg body
weight intravenous at 5% solution in normal saline. After 5 minutes, anaesthesia was
induced by administration of ketamine at the dose rate of 3 mg/kg body weight and
midazolam at the dose rate of 0.30 mg/kg body weight intravenous bolus and maintained
with isoflurane (1-2%). Induction time was significantly earlier in group-I animals. The
recovery time, recovery time to assume sternal recumbency, recovery time to standing
position was significantly quicker in group-II animals. The degree of analgesia and muscle
relaxation was significantly greater in both the group of cattle. Physiological parameters
like heart rate, respiratory rate and rectal temperature decreased significantly in both the
group of cattle, however they were within the normal physiological limits. Haematological
parameters and biochemical parameters though changed significantly during depth of
general anaesthesia in both the groups was only transient, however they were within the
physiological limits. The present study concluded that, both the anaesthetic combinations
(group-I and group-II) are excellent to use for orthopaedic surgeries in cattle.