Evaluation Of Pentazocine Alone And In Combination With Diazepam In Goats
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Date
1989
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Birsa Agricultural University, Ranchi
Abstract
On the basis of the present experimental study, the following conclusions are drawn:
1. Pentazocine and diazepam combination produces optimal sedation but narrow range muscle relaxation in goats.
2. Abolition of superficial and deep cutaneous reflexes, permitting surgical intervention, without impairment of consciousness, are restricted to the limbs and abdomen.
3. Pentazocine alone does not exert its influence, to clinically satisfactory level, on any feature as indicated in sl. no. 1 and 2 above.
4. Fall in rectal temperature with combination is explicit but hypothermia does not appear to be a characteristic of pentazocine administration.
5. Hematological profile appears to be convince ingly altered in some of the parameters by either means of administration, but these are transitory.
6. SGOT changes in response to pentazocine or its diazepam combination may suggest involvement of liver, but the effects being short-lived and within physiological limits make them to be inconsequential.
7. There may be fluctuating rise and fall in blood glucose level but these are not sustained to constitute hyper or hypoglycemic states in goats.
8. Finally, pentazocine may be very potent in alleviating all types of pain, its ability to prevent induced pain is conjectural.