Elucidation of phytoconstituents and antioxidant & in vitro antiinflammatory activities of nine members of family Lamiaceae
| dc.contributor.advisor | Rao, P.B. | |
| dc.contributor.author | Thakurathi, Gayatri | |
| dc.date.accessioned | 2019-08-27T07:06:34Z | |
| dc.date.available | 2019-08-27T07:06:34Z | |
| dc.date.issued | 2019-06 | |
| dc.description.abstract | Medicinal herbs offer an important traditional way to prevent and cure several diseases. Various anti-inflammatory drugs have been used to reduce pain and inflammation. However, there are many side effects associated with non- steroidal drugs. Therefore, a search for non-toxic natural compounds with antioxidant activity has intensified in recent years. In the present study, nine wild plant species of family Lamiaceae were selected to assess their antioxidant and anti-inflammatory potential. The extraction yield (%) was maximum in Pogostemon benghalensis (21.01) and Vitex negundo (18.71) in aqua-methanol and aqua-acetone, respectively. All the phytochemicals are present in all the species except saponins present in Clerodendrum infortunatum, Colebrookea oppositifolia and V. negundo; terpenoids were absent in Roylea elegans. In both aqua-methanol and aqua-acetone, the values in different plant species was maximum in C. oppositifolia in terms of DPPH (80.17 and 70.35 %), FRAP (109.38 and 83.72, μg BHTE/mg), FCA (57.1 and 54.55 μg BHTE/mg) and TAA (116.13 and 69.95 μg VCE/mg) assays, respectively. The TPC (μg GAE/mg) was maximum in C. oppositifolia (36.10) and P. benghalensis (30.20) in aqua-methanol and aqua-acetone, respectively while the TFC ((μg QE/mg) was maximum in V. negundo (41.93 and 44.266) in both aqua-methanol and aqua-acetone. The IC50 values (μg/ml) of DPPH were comparatively higher in R. elegans (409.0) in aqua-methanol and Lamium amplexicaule (178.97) in aqua-acetone and low in C. oppositifolia (26.17 and 41.08 in aqua-methanol and aqua-acetone, respectively); and IC50 values of FCA ranged from 106.13 (C. oppositifolia) to 594.69 (V. negundo) in aqua-methanol; and 111.608 (C. oppositifolia) to 676.48 (R. elegans) in aqua-acetone. Anti-inflammatory potential against protein denaturation (%) was comparatively higher in C. oppositifolia in both aqua-methanol (73.93) and aqua-acetone (64.78) than other species. Among the solvents, aqua-methanol showed comparatively higher antioxidant activity than aqua-acetone. Positive and significant correlation in terms of FRAP, DPPH, FCA, TAA and TPC was obtained in all species. Thus, the above mentioned plant species with comparatively higher antioxidant and anti-inflammatory potential than the others and can be a potent natural plant source of nutritional and anti-inflammatory drugs which can be utilized for developing natural curatives against synthetic ones. It can be exploited in nutraceutical and pharmaceutical industries. | en_US |
| dc.identifier.uri | http://krishikosh.egranth.ac.in/handle/1/5810124089 | |
| dc.keywords | chemical constituents of plants, antioxidants, in vitro, antiinflammatory agents, Lamiaceae, medicinal plants | en_US |
| dc.language.iso | en | en_US |
| dc.pages | 142 | en_US |
| dc.publisher | G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand) | en_US |
| dc.research.problem | Antiinflammatory Properties | en_US |
| dc.sub | Botany | en_US |
| dc.subject | null | en_US |
| dc.theme | Medicinal Plants | en_US |
| dc.these.type | M.Sc | en_US |
| dc.title | Elucidation of phytoconstituents and antioxidant & in vitro antiinflammatory activities of nine members of family Lamiaceae | en_US |
| dc.type | Thesis | en_US |