ROMIFIDINE AND XYLAZINE SEDATION WITH KETAMINE-ISOFLURANE ANAESTHESIA FOR SURGERIES IN BUFFALOES
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Date
2019-08
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KARNATAKA VETERINARY, ANIMAL AND FISHERIES SCIENCES UNIVERSITY, BIDAR
Abstract
The present study was carried out in 12 clinical cases of buffaloes of either sex
presented for various surgical procedures at Veterinary College, Bidar. The sedative
effects of romifidine and xylazine for ketamine-isoflurane general anaesthesia in
buffaloes were compared. The buffaloes were randomly divided into two groups
consisting of six buffaloes in each group. The buffaloes of group I were administered
with romifidine hcl @ 10 μg/kg body weight IV followed by ketamine hydrochloride @
(3 mg/kg, I/V) and maintained with isoflurane @ (1-2 %). The buffaloes of group II were
administered with xylazine @ 0.1 mg/kg body weight IV followed by ketamine
hydrochloride @ (3 mg/kg, I/V) and maintained with isoflurane @ (1-2%). The
anaesthetic combinations were evaluated based on clinical, physiological, haemodynamic
and haematobiochemical observations. Onset of sedation and down time to sternal
recumbency was faster in the buffaloes premedicated with romifidine. Better analgesia,
degree of sedation, muscle relaxation and faster induction and recovery was noticed in
romifidine group-I as compared to xylazine group-II for ketamine-isoflurane general
anaesthesia in buffaloes. Respiratory depression, bradycardia and decrease in mean
arterial pressure were more severe in buffaloes premedicated with romifidine when
compared to buffaloes premedicated with xylazine during ketamine-isoflurane
anaesthesia. Haematobiochemical parameters though changed non-significantly during
general anaesthesia in both the groups, it was only transient and not alaraming to suggest
any pathological condition. Hence romifidine as a premedicant can be preferred over
xylazine ketamine-isoflurane induced general anaesthesia buffaloes