Fabrication of Progesterone-Loaded Nanofibers for the Drug Delivery Applications in Bovine

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dc.contributor.authorKaruppannan, Chitra
dc.contributor.authorSivaraj, Mehnath
dc.contributor.authorGanesh Kumar, J
dc.contributor.authorSeerangan, Rangasamy
dc.contributor.authorBalasubramanian, S
dc.contributor.authorGopal, Dhinakar Raj
dc.contributor.authorTANUVAS
dc.date.accessioned2020-06-15T06:30:44Z
dc.date.available2020-06-15T06:30:44Z
dc.date.issued2017
dc.descriptionTNV_NRL_2017_12(116)1-6en_US
dc.description.abstractProgesterone is a potent drug for synchronization of the estrus and ovulation cycles in bovine. At present, the estrus cycle of bovine is controlled by the insertion of progesterone-embedded silicone bands. The disadvantage of nondegradable polymer inserts is to require for disposal of these bands after their use. The study currently focuses on preparation of biodegradable progesterone-incorporated nanofiber for estrus synchronization. Three different concentrations (1.2, 1.9, and 2.5 g) of progesterone-impregnated nanofibers were fabricated using electrospinning. The spun membrane were characterized by scanning electron microscopy, X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, and Fourier transform infrared spectroscopy. Uniform surface morphology, narrow size distribution, and interaction between progesterone and zein were confirmed by SEM. FTIR spectroscopy indicated miscibility and interaction between zein and progesterone. X-ray analysis indicated that the size of zein crystallites increased with progesterone content in nanofibers. Significant differences in thermal behavior of progesterone-impregnated nanofiber were observed by DSC. Cell viability studies of progesterone-loaded nanofiber were examined using MTT assay. In vitro release experiment is to identify the suitable progesterone concentration for estrus synchronization. This study confirms that progesterone-impregnated nanofibers are an ideal vehicle for progesterone delivery for estrus synchronization of bovines.en_US
dc.identifier.urihttp://krishikosh.egranth.ac.in/handle/1/5810147612
dc.keywordsZein, Electrospinning, Nanofibers, Progesterone, Estrus synchronizationen_US
dc.language.isoenen_US
dc.pages1-6en_US
dc.subjectVeterinary Scienceen_US
dc.titleFabrication of Progesterone-Loaded Nanofibers for the Drug Delivery Applications in Bovineen_US
dc.title.alternativeNanoen_US
dc.typeArticleen_US
dc.volume12en_US
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