Clinical adaptation of Tiletamine and Zolazepam drug combination for conducting different diagnostic and surgical procedures in dogs

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dc.contributor.advisorKumar, Amit
dc.contributor.authorK, Vijaya Mahantesh S
dc.date.accessioned2023-03-04T10:18:54Z
dc.date.available2023-03-04T10:18:54Z
dc.date.issued2023-02-06
dc.description.abstractThe study was conducted for the clinical evaluation of Tiletamine-zolazepam when used alone and in combination with inj. atropine, inj. butorphanol and either xylazine or dexmedetomidine in 26 client owned dogs divided into 3 groups group 1 (n=8), group 2 (n=8) and in group 3 (n=10). Dogs presented for various minor and non invasive surgical manipulation were placed in group 1 and for ovariohysterectomy were placed in groups 2 and 3. The drug regime for group 1 (n=8) involved administration of tiletamine-zolazepam at the dose rate of 7.0 mg/kg alone whereas inj. butorphanol @ 0.2 mg/kg and inj. atropine @ 0.04 mg/kg were used in for group 2 and 3 followed by inj. xylazine @ 1.0 mg/kg along with tiletamine-zolazepam @ 3.3 mg/kg in group 2 and dexmedetomidine @ 10 µg/kg along with tiletamine-zolazepam @ 4.5 mg/kg in group 3 were used. These doses were standardized after pilot trails. All the animals received 100 per cent oxygen throughout the study period. Parameters under investigation included intra-operative behaviour and sedation parameters in group 1 and analgo-clinical observations, cardiovascular parameters, pulmonary parameters, haemato-biochemistry, electrolytes and recovery parameters. Animals in all the three groups showed smooth induction with adequate muscle relaxation and analgesia. Significant decrease in rectal temperature was noticed in all the three groups which improved during recovery. ECG parameters did not show significant difference from physiological values in majority of animals. Significant increase in heart rate was noticed after induction in all the three groups which came back to normal value at the end of the study period. Non-invasive blood pressure showed non-significant increase in all the three groups initially and later decreased lesser than the baseline value. SpO2, EtCO2 and FiCO2 values remained within the normal range throughout the procedure. Significant decrease in respiration rate was noticed in group 2 and group 3 with no incidence of apnea. Hematological parameters reduced non-significantly at the end of the study period when compared with baseline value in group 2 and 3. Biochemical parameters and electrolytes did not vary significantly throughout the study period except for glucose which showed a significant increase throughout the study period in both the groups. Recovery period was longer in group 3. Post-operative vocalization, paddling, curling of tongue and nystagmus was noticed in animals of group 1 and vocalization with ataxia and head bobbing was noticed in some animals of group 2 and group 3 which abolished after recovery without any adverse consequences. The above protocol used in the study provided safe and adequate anaesthesia for different surgical manipulations that can be performed under 60 minutes in dogs.en_US
dc.identifier.urihttps://krishikosh.egranth.ac.in/handle/1/5810194787
dc.keywordsDogs, Diagnostic procedures, Surgical procedures, Clinical adaptation, Tiletamine, Zolazepam, Anaesthesia,en_US
dc.language.isoEnglishen_US
dc.pages115en_US
dc.publisherCSK HPKV, Palampuren_US
dc.subVeterinary Surgery and Radiologyen_US
dc.themeTo evaluate clinical efficacy of Tiletamine and Zolazepam alone and in combination with other drugs for performing different diagnostic and surgical procedures in dogs.en_US
dc.these.typeM.V.Sc.en_US
dc.titleClinical adaptation of Tiletamine and Zolazepam drug combination for conducting different diagnostic and surgical procedures in dogsen_US
dc.typeThesisen_US
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