EVALUATION OF RENAL FUNCTION IN DOGS AFFECTED WITH PYOMETRA
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Date
2023-04
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SRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI - 517 502. (A.P.) INDIA
Abstract
The present study was undertaken to study the renal dysfunction in dogs affected
with pyometra. The occurrence of pyometra was observed to be 2.02 per cent among a
total of 1383 female dogs presented during the study period. The pyometra dogs were
subjected to detailed clinical and haemato-biochemical examination to assess renal
function in dogs. In the present study, based on elevated levels of serum creatinine and
BUN values, the pyometra dogs were categorized as azotemic (Group I) and non
azotemic (Group II). The occurrence of azotemia (Group I) in dogs accounted up to 42.86
per cent whereas 57.14 per cent were non-azotemic (Group II). The occurrence of
pyometra with or without azotemia was more in Pomeranian breed with majority of the
dogs in the age group of 5-10 years. Clinical examination was performed to assess SIRS
in pyometra dogs and revealed 36.84 per cent (Group I) and 63.16 per cent (Group II) of
pyometra affected dogs were SIRS positive.
Haematological examination revealed decreased haemoglobin, total erythrocyte
count, lymphocyte count along with leucocytosis. DLC revealed neutrophilia with shift
to left. Biochemical examination revealed elevated mean serum creatinine (mg/dL), BUN
(mg/dL) and CRP (mg/L), hypoalbuminemia and hypochloremia in pyometra dogs with
and without azotemia when compared to healthy control while hyponatremia was
observed in azotemic bitches. Urinalysis revealed decreased specific gravity and
elevation of UPCR, which showed significant difference (P<0.01) between the two
groups. The prominent nephrosonographic features observed in azotemic dogs were
irregular contour, indistinct cortico-medullary junction, increased/decreased cortical
echogenecity and nephrocalcinosis. Doppler ultrasonography was performed to assess
haemodynamic changes in kidneys revealed that the mean resistive index (RI) and the
mean pulsatility index (PI) were significantly (P<0.01) elevated in pyometra dogs than
healthy control. Pearson’s correlation did not demonstrate significant correlation between
serum creatinine with RI and PI (P>0.05) in the present study. Significant reduction in
the mean±SE of serum creatinine (P<0.01) and mean±SE of serum BUN (P<0.05)
following ovario-hysterectomy as compared to pre-operative values suggested that renal
dysfunction was transient in most of the pyometra dogs.