STUDIES ON THERAPEUTIC EFFICACY OF SILYMARIN IN HEPATIC DISORDERS WITH SPECIAL REFERENCE TO ASCITES IN DOGS
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Date
2018-05-05
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Dau Shri Vasudev Chandrakar Kamdhenu Vishwavidyalaya Durg
Abstract
"Man's best friend" is a common phrase for domestic dogs, referring to their
millennia-long history of close relations, loyalty and companionship with humans and also
provide physiological and psychological benefits. Liver plays a pivotal role in the regulation
of body metabolism, secretion and detoxification process of many substances. It is the largest
parenchymal organ in the body having the biological property of tremendous storage
capacity, functional reserve and regenerative capabilities. Ascites is defined as pathological
accumulation of serous fluid in the peritoneal cavity. Among the abdominal abnormalities of
dogs, ascites is commonly encountered condition. Ascites is always an indication of disease,
therefore thorough investigation should be aimed at identifying the underlying primary
condition. The pathogenesis of ascites is related to protein deficiency and renal, hepatic and
cardiovascular insufficiencies.
The study was conducted to assess the therapeutic efficacy of silymarin in ascites in
dogs. A total of 1,608 dogs irrespective of age, breed and sex from various sources i.e. dogs
presented to T.V.C.C., Anjora and different Government Veterinary Hospitals in and around
Durg were included in the present study. Based on clinical examination, 29 dogs were found
to be positive for ascites of hepatic origin.
The prevalence of ascites of hepatic origin in the present study was 1.803%. Age wise
prevalence revealed that dogs of age group between 3-5 years were mostly affected as
compared to all other age groups. Breed wise prevalence revealed that Labredor retriever was
most commonly affected breed as compared to other breeds with no sex predisposition.
Reduced Hb, PCV were recorded in ascitic dogs. Hypoproteinemia,
hypoalbuminemia, hypoglobulinemia and hyperbilirubinemia with increased ALP and GGT
levels were the main serum biochemical alteration in ascitic dogs. Ultrasonography revealed
anechoic anechoic fluid of variable degree filled inside abdominal cavity.
A total of 21 dogs suffering from ascites of hepatic origin were divided into 3 groups
I, II and III for therapeutic regimen. Clinical signs and vital parameters were noticed to have
improved after 21 days of treatment in all the groups with better improvement in Group III
dogs. The hemato-biochemical and USG alterations in ascites affected dogs revealed mild
alterations which returned to normal values over the due course of treatment.
On the basis of clinical signs of improvement along with restoration of hemato-biochemical parameters, it was observed that Silymarin @50 mg/kg b.wt along with
supportive therapy proved better in therapeutic management of ascites of hepatic origin in
dogs.