ASSESSMENT OF WOUND HEALING FOLLOWING COLLAGEN URETHRAL STENT PLACEMENT FOR URETHROTOMY IN DOGS
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Date
2021
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Abstract
Urethral obstruction is an emergency clinical scenario in dogs which leads
to post-renal azotemia due to obstruction of urine flow. The most common cause
of urethral obstruction is urolithiasis which was diagnosed with ultrasonography
and radiography in the present study.
A total of 12 animals presented to Madras Veterinary College teaching
hospital with the history of urinary obstruction were chosen for the study and were
randomly divided into 2 groups of 6 animals each. Group I animals were treated
with conventional urethrotomy procedure and group II animals were treated with
urethrostomy with collagen urethral stent placement. The collagen material used
was an acellular matrix of bovine origin. The acellular collagen matrix was
tubularised into urethral stent and placed inside the urethra and the urethrotomy
was closed and the surgical wound was evaluated post-operatively for 14 days.
Haemato-biochemical parameters were assessed pre-operatively and post operatively on days 0, 3, 7 and 14 and found that the renal parameters were
significantly different in both the groups I and II between the pre-operative and
post-operative period indicating the change in renal function before and after
relieving the urethral obstruction. Plain and contrast radiography were used to
determine the urethral lumen diameter and urethral leakage post-operatively in
both the groups I and II which revealed no urethral leakage or urethral stricture
post-operatively in both the groups indicating that acellular collagen matrix
prevented urethral leakage and stricture. Ultrasonography was used to assess the
collagen stent absorption, collapse and migration post-operatively in group II
animals. There was no collagen stent collapse or stent migration in any of the
animals in group II. Ultrasound revealed a partial absorption of collagen stent on
day 7 and a complete absorption at day 14 post-operatively. Short Form of
Glassgow Composite Measure Pain Scale (CMPS-SF) was used to evaluate acute
pain in this study on 3"*, 7^ and 14^ post-operative days. There was no
significant difference in the pain scores between the groups indicating that the
collagen stent does not elicit any extra pain than normal urethrotomy procedure.