A rare case of non-cystic osteitis fi brosa in a twelve week-old male Wistar rat
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Date
2023
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Abstract
A case of non-cystic osteitis fi brosa was observed as a spontaneous lesion in a twelve week-old male Wistar rat from a
repeated dose toxicity study. The rat did not show abnormal clinical signs, changes in food consumption and body weight gain
throughout the study period. No abnormalities were noticed for haemato-biochemical parameters. The bone marrow cytology
of the rat showed no pathological alterations. Histopathological examination of femur showed moderate fi brosis along with
mononuclear cell infi ltration, increased multinucleated osteoclastic activity and few osteoblasts. Other organs of the rat did not
reveal any abnormalities. These fi ndings were suggestive of osteitis fi brosa with no cyst formation.