Intriguing Role of Lysophosphatidic Acid (LPA) and its Receptor Mediated Signaling during Implantation: A Review
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Date
2020-06
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Abstract
Regardless of major advances in medical technologies many Assisted Reproductive
Technology (ART) experience recurrent implantation failures (RIF). Lysophosphatidic acid
(LPA) signaling cross talks between the mother and the implanted embryo at a very early stage
of gestation to enhance endometrium receptivity. LPA is a simple water soluble phospholipid
that arbitrates varied biological functions like proliferation, migration and activation of various
intracellular signaling pathways in diverse cell types. LPA also has a chief role to play in
human and animal reproductive processes including luteolysis, endometrium and ovarian
function, estrous cycle regulation, embryo development and implantation, placentation and
decasualization with the help of receptor (LPAR1-6) mediated LPA signaling. Further,
autotaxin a LPA producing enzyme is found to be upregulated during decasualization of human
endometrial stromal cells (HESC). LPA aids in the maintenance of endometrium receptivity by
invigorating the expression of prostaglandin endoperoxide synthase 2 (PTGS2). LPA also
increases progesterone (P4) and prostaglandin E2 (PGE2) secretion and elevation in
PGE2/PGF2α ratio. This review highlights and discusses about the current advancement in
receptor mediated LPA signaling in human reproduction, ruminant reproduction pointing to
bovine and sheep models, and even in porcine reproduction models and correlating it with
human reproductive function.
Description
TNV_IJCMAS_2020_9(6)2381-2389
Keywords
Veterinary Science