Intriguing Role of Lysophosphatidic Acid (LPA) and its Receptor Mediated Signaling during Implantation: A Review

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dc.contributor.authorMadhumitha, B
dc.contributor.authorReena, D
dc.contributor.authorManokaran, S
dc.contributor.authorTANUVAS
dc.date.accessioned2020-07-06T08:57:45Z
dc.date.available2020-07-06T08:57:45Z
dc.date.issued2020-06
dc.descriptionTNV_IJCMAS_2020_9(6)2381-2389en_US
dc.description.abstractRegardless of major advances in medical technologies many Assisted Reproductive Technology (ART) experience recurrent implantation failures (RIF). Lysophosphatidic acid (LPA) signaling cross talks between the mother and the implanted embryo at a very early stage of gestation to enhance endometrium receptivity. LPA is a simple water soluble phospholipid that arbitrates varied biological functions like proliferation, migration and activation of various intracellular signaling pathways in diverse cell types. LPA also has a chief role to play in human and animal reproductive processes including luteolysis, endometrium and ovarian function, estrous cycle regulation, embryo development and implantation, placentation and decasualization with the help of receptor (LPAR1-6) mediated LPA signaling. Further, autotaxin a LPA producing enzyme is found to be upregulated during decasualization of human endometrial stromal cells (HESC). LPA aids in the maintenance of endometrium receptivity by invigorating the expression of prostaglandin endoperoxide synthase 2 (PTGS2). LPA also increases progesterone (P4) and prostaglandin E2 (PGE2) secretion and elevation in PGE2/PGF2α ratio. This review highlights and discusses about the current advancement in receptor mediated LPA signaling in human reproduction, ruminant reproduction pointing to bovine and sheep models, and even in porcine reproduction models and correlating it with human reproductive function.en_US
dc.identifier.urihttp://krishikosh.egranth.ac.in/handle/1/5810148673
dc.keywordsLysophosphatidic acid (LPA), Assisted Reproductive Technology (ART), Recurrent implantation failure (RIF), Autotaxinen_US
dc.language.isoenen_US
dc.pages2381-2389en_US
dc.relation.ispartofseries;6
dc.subjectVeterinary Scienceen_US
dc.titleIntriguing Role of Lysophosphatidic Acid (LPA) and its Receptor Mediated Signaling during Implantation: A Reviewen_US
dc.title.alternativeInternational Journal of Current Microbiology and Applied Sciencesen_US
dc.typeArticleen_US
dc.volume9en_US
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