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Assam Agricultural University, Jorhat

Assam Agricultural University is the first institution of its kind in the whole of North-Eastern Region of India. The main goal of this institution is to produce globally competitive human resources in farm sectorand to carry out research in both conventional and frontier areas for production optimization as well as to disseminate the generated technologies as public good for benefitting the food growers/produces and traders involved in the sector while emphasizing on sustainability, equity and overall food security at household level. Genesis of AAU - The embryo of the agricultural research in the state of Assam was formed as early as 1897 with the establishment of the Upper Shillong Experimental Farm (now in Meghalaya) just after about a decade of creation of the agricultural department in 1882. However, the seeds of agricultural research in today’s Assam were sown in the dawn of the twentieth century with the establishment of two Rice Experimental Stations, one at Karimganj in Barak valley in 1913 and the other at Titabor in Brahmaputra valley in 1923. Subsequent to these research stations, a number of research stations were established to conduct research on important crops, more specifically, jute, pulses, oilseeds etc. The Assam Agricultural University was established on April 1, 1969 under The Assam Agricultural University Act, 1968’ with the mandate of imparting farm education, conduct research in agriculture and allied sciences and to effectively disseminate technologies so generated. Before establishment of the University, there were altogether 17 research schemes/projects in the state under the Department of Agriculture. By July 1973, all the research projects and 10 experimental farms were transferred by the Government of Assam to the AAU which already inherited the College of Agriculture and its farm at Barbheta, Jorhat and College of Veterinary Sciences at Khanapara, Guwahati. Subsequently, College of Community Science at Jorhat (1969), College of Fisheries at Raha (1988), Biswanath College of Agriculture at Biswanath Chariali (1988) and Lakhimpur College of Veterinary Science at Joyhing, North Lakhimpur (1988) were established. Presently, the University has three more colleges under its jurisdiction, viz., Sarat Chandra Singha College of Agriculture, Chapar, College of Horticulture, Nalbari & College of Sericulture, Titabar. Similarly, few more regional research stations at Shillongani, Diphu, Gossaigaon, Lakhimpur; and commodity research stations at Kahikuchi, Buralikson, Tinsukia, Kharua, Burnihat and Mandira were added to generate location and crop specific agricultural production packages.

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2021 - 20222
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Subject: Veterinary Pharmacology and Toxicology × End date: 2022 × Start date: 2020 ×
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    ThesisItemOpen Access
    Evaluation of wound healing properties of Zanthoxylum Oxyphyllum: an indigenous medicinal plant
    (College of Veterinary Science, Assam Agricultural University, Khanapara Campus, 2022-03) Rabha, Kushal; Mohan, Pritam
    The present study was conducted to evaluate the wound healing and analgesic properties of hydro-ethanolic and chloroform extract of Zanthoxylum oxyphyllum in rats and mice. The selected plant was also studied for phytochemical constituents, anti-oxidant properties, and acute oral and dermal toxicity of both the extracts. The dried pulverized fine powder of Zanthoxylum oxyphyllum were extracted using a standard technique where hydro-ethanolic and chloroform extract yield were found to be 14% and 6% respectively. The extracts were found to be positive for Alkaloids, Steroids, Flavonoids, Phenols, Carbohydrates, Diterpenes, Triterpenes and negative for Glycosides, Tannins and Saponins. The extracts did not show any acute oral or dermal toxicity even at the highest oral dose level, i.e., 5000 mg/kg body weight of all the groups. Both the hydro ethanolic and chloroform extract of the selected plants were positive for antioxidant properties, Viz, DPPH and Nitric oxide scavenging activity. The analgesic activity of both the extracts viz hydroethanolic and chloroform extract were evaluated by using Eddy’s hot plate analgesiometer and acetic acid induced writhing test where animals were divided in eight groups with each group having six animals. Group I served as normal control with no treatment and Group II as standard control received oral meloxicam suspension @ 5mg/kg. Other six groups were test groups where hydroethanolic and chloroform extract of Zanthoxylum oxyphyllum were administered in 10, 30 and 100 mg/kg concentrations. In case of Eddy’s hot plate method, both the extracts showed significant increase in latency period after administration of 10, 30, or 100 mg/kg orally to the mouse. The writhing responses were also markedly reduced after administration of 10, 30, and 100 mg/kg hydroethanolic and chloroform extract of Z. oxyphyllum as compared to the control. Both excision and incision wound models were created in rats using xylazine-ketamine anaesthesia and wound contraction percentage and breaking strength of the wound were measured respectively. The test ointments were prepared in 1%, 3% and 10% w/w concentrations for both hydroethanolic and chloroform extract using Vaseline. Rats were randomly divided in groups of nine of six animals in each group for both the wound models. Group I, Group II and group III served as normal (untreated), vehicle (petroleum jelly) and standard (povidone iodine) control groups. Other six groups were treated topically with test ointments of hydro-ethanolic and chloroform extract of Zanthoxylum oxyphyllum. In case of incision wound model, the wound breaking strengths were markedly increased after application of both the extracts when compared to the normal and vehicle control groups. The differences were not statistically significant at 1% level of the standard control, 1%, 3%, and 10% w/w extract groups of Zanthoxylum oxyphyllum. Maximum breaking strength was observed in higher concentrations, i.e., 10% w/w extract of Zanthoxylum oxyphyllum. In case of excision wound model, the wound contraction percentage elevated significantly in standard and extract treated groups as compared to the normal and vehicle control groups. The higher (10%) concentration of extract showed higher wound contraction (%) as compared to the other two extract groups
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    ThesisItemOpen Access
    Evaluation of wound healing properties of flacourtia jangomas and pongamia pinnata
    (College of Veterinary Science, Assam Agricultural University, Khanapara Campus, 2021) Rahman, Farida; Mohan, Pritam
    The present study was undertaken to evaluate the wound healing property of hydroethanolic and chloroform extracts of two different medicinal based plant Flacourtia jangomas and Pongamia pinnata on excision, incision, dead space and diabetic wound model. Each experiment was carried out for 12 days separately. Extracts were prepared from the barks of Flacourtia jangomas and seeds of Pongamia pinnata plant. A total of 384 albino rats of Wistar strain were divided into two groups each for Flacourtia jangomas and Pongamia pinnata plant having eight subgroups consist of six rats per group. The extracts were applied topically at the dose rate of 1%, 2.5% and 5% on excision, incision and diabetic wound model. For dead space wound model extracts were administered orally at the dose rate of 100, 300 and 900 mg/kg body weight to evaluate the toxic effect of the extracts on different blood biochemical parameters along with its wound healing potential. Wound healing efficacy was assessed by the rate of wound contraction, epithelialization period, breaking strength for excision and incision wound model; wet and dry weight of granulation tissue and its hydroxyprolein content was measured for dead space wound model. In vivo antioxidant activity was also estimated in blood and tissues on the last day of the experiment. Phytochemical study of both the plant extract of Flacourtia jangomas and Pongamia pinnata revealed the presence of alkaloid, flavonoid, terpenoids, tannin, saponin, glycosides and steroid. Result of the present study revealed, topical application of the ointments prepared from the respective plants exhibited its healing potential in a dose dependent manner at different significant level of (P<0.05, P<0.01, P<0.001), as evident from the decreased in wound size, epithelialization period and increased in tensile strength. Wet and dry weight of granulation tissue and its hydroxyprolein content were also well correlated with the healing pattern observed. Oxidative stress was also found to be ameliorated by the treatment with the plant extracts during healing process. On the other hand, toxicological evaluation of the extracts on different blood biochemical parameters, such as AST, ALT, ALP, glucose, cholesterol, creatinine total protein and urea did not show any significant alteration on 0 and 12th day of the experiment. From the present study it can be concluded that both the plant extracts have good wound healing property and chloroform extract of Pongamia pinnata plant showed better efficacy and can be used commercially due to its easy availability.