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Govind Ballabh Pant University of Agriculture and Technology, Pantnagar

After independence, development of the rural sector was considered the primary concern of the Government of India. In 1949, with the appointment of the Radhakrishnan University Education Commission, imparting of agricultural education through the setting up of rural universities became the focal point. Later, in 1954 an Indo-American team led by Dr. K.R. Damle, the Vice-President of ICAR, was constituted that arrived at the idea of establishing a Rural University on the land-grant pattern of USA. As a consequence a contract between the Government of India, the Technical Cooperation Mission and some land-grant universities of USA, was signed to promote agricultural education in the country. The US universities included the universities of Tennessee, the Ohio State University, the Kansas State University, The University of Illinois, the Pennsylvania State University and the University of Missouri. The task of assisting Uttar Pradesh in establishing an agricultural university was assigned to the University of Illinois which signed a contract in 1959 to establish an agricultural University in the State. Dean, H.W. Hannah, of the University of Illinois prepared a blueprint for a Rural University to be set up at the Tarai State Farm in the district Nainital, UP. In the initial stage the University of Illinois also offered the services of its scientists and teachers. Thus, in 1960, the first agricultural university of India, UP Agricultural University, came into being by an Act of legislation, UP Act XI-V of 1958. The Act was later amended under UP Universities Re-enactment and Amendment Act 1972 and the University was rechristened as Govind Ballabh Pant University of Agriculture and Technology keeping in view the contributions of Pt. Govind Ballabh Pant, the then Chief Minister of UP. The University was dedicated to the Nation by the first Prime Minister of India Pt Jawaharlal Nehru on 17 November 1960. The G.B. Pant University is a symbol of successful partnership between India and the United States. The establishment of this university brought about a revolution in agricultural education, research and extension. It paved the way for setting up of 31 other agricultural universities in the country.

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  • ThesisItemOpen Access
    Electroencephalographic and electrocardiographic studies on propofol anaesthesia in sheep
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2011-06) Raj Kumari; Das, Arup Kumar
    In this study electroencephalographic and electrocardiographic changes during surgical interventions {viz., placement of central venous catheters (Group-B), docking/ tail amputation (Group-C), bilateral orchiectomy (Group-D) and no surgical stimuli as control (Group-A)} with propofol anaesthesia were assessed in twenty-four (n=24) apparently healthy male sheep. For surgical operations each sheep of this study was premedicated with glycopyrrolate (@ 0.02 mg/kg body weight, IM) and, five minutes after, anaesthesia was induced with propofol (@ 4.00 mg/kg body weight, IV). The parameters in this study included clinical, cardiopulmonary, haematobiochemical and electrocardiographic parameters. Similarly, qualitative electroencephalographic evaluation was done through spectral analysis to generate total power, SEF-90, MF and PPF over 0-30 frequency band width while relative power of different bandwidths viz., , , and was assessed. Rectal temperature and respiration rate has not shown any significant variability in any of the groups during the entire course of experiment. Haemoglobin concentration reduced and this extent was higher in control group than central venous catheterization, docking and castration groups. PCV reduced in all the groups. TEC depicted reduction in control group; however, this fall was not apparent in other groups. Blood glucose decreased initially followed by an increase in three groups after propofol induction while the castration group exhibited a non-significant increase from very beginning. Total serum protein declined in all the groups. A sudden increase in serum triglyceride (TG) was observed at one minute post-propofol induction in all the groups, which later on declined. Propofol has not been able to induce any significant changes in P-wave, QRS wave and T-wave amplitude as exhibited in control group. However, P-wave amplitude increased significantly in animals performed with central venous catheterization. The T-wave amplitude increased nonsignificantly in CVC group while decrease in docking and castration groups. P-wave and T-wave duration has not exhibited any significant difference throughout the course of experiment. However, QRS wave duration decreased in control group and no significant changes were observed in surgical groups. PR segment length reduced in castration group only and none of the other groups exhibited any significant changes. ST segment length exhibited significant increase in control group, non-significant increase in CVC while exhibiting significant fall in castration and docking groups. RR interval exhibited reduction in all the four groups, non-significantly in control while significantly in the three surgical groups. Heart Rate increased in all the four groups. EEG analysis showed an increase in total power, median frequency, theta frequency, peak power in all group, and after a transient increase reduction in spectral edge frequency and alpha frequency. However delta frequency showed an increase after a transient decrease and a marked decrease in beta frequency after propofol injection. It was concluded that propofol to some extent possess analgesic effect and may be useful in husbandry practices/ day case surgery. However, evaluation of analgesic effects of propofol needs further investigation.
  • ThesisItemOpen Access
    Studies on anaesthetic and surgical management of traumatized canine patients
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2006-11) Ram Lakhan; Sharma, V.K.
    The sixteen clinical cases of traumatized canine patients brought to Veterinary Teaching Hospital were screened by clinical and radiographic observations and divided into two groups viz. A and B. The animals of group A were suffering with hard tissue trauma while the animals of group B were suffering with soft tissue trauma. Besides this another group (C) comprised of 8 healthy dogs was also used as a control study. The pathophysiological alterations in the traumatized animals were determined by measuring the level of different clinicophysiological and haematobiochemical parameters. The animals of group A and B were further divided into subgroups A1, A2, B1 and B2 having equal number of dogs. The animals of subgroups A1 and B1 were subjected to the surgical intervention under the effect of atropine, diazepam, thiopental sodium, and halothane anaesthesia while the animals of subgroups of A2 and B2 were operated under the effect of atropine, diazepam, thiopental sodium and isoflurane anaesthesia. The animals of subgroups A1and B1 were subjected to intravenous administration of Ringer lactate and haemaccel while the animals of subgroup A2 and B2 were subjected to intravenous administration of Ringer lactate and normal saline. Moxel @ 10 mg/kg body weight intramuscular BID for 7 days was administered in all injured animals post operatively. Various clinicophysiological, cardiopulmonary and haematobiochemical parameters were determined to measure the pathophysiological alteration and efficacy of different combination of anaesthetic agent. On the basis of these parameters it was concluded that the pathophysiological changes in hard tissue trauma were more marked as compared to soft tissue trauma. The combination of atropine, diazepam, thiopental sodium and halothane in both groups of animals as it provides more cardiopulmonary stability and has least deleterious effect on different body system. In post operative period the combination of Ringer lactate and haemaccel was more effective than the Ringer lactate and normal saline as it has altered the pathophysiological more quickly.
  • ThesisItemOpen Access
    Surgical management of distal radius and ulna fracture in dogs with special reference to Colles fracture - a comparative study
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2006-01) Bhagavantappa, B.; Das, Arup Kumar
    Twenty-four clinical cases with distal radius and ulna fracture (Colles Type) in dogs admitted in Veterinary Teaching Hospital, Pantnagar were considered for the evaluation of different fixation techniques. Cases were randomly divided into four groups, viz. I (treated with ESF- Type I or Type II configuration), II (treated with stainless steel T-plate – 2.5 or 3.5 mm with five holes), III (treated with Ilizarov ring fixator: CESF) and IV (treated with plaster of Paris cast). The anaesthetic regimen with atropine sulphate and diazepam premedication and induction of general anaesthesia with thiopental sodium intravenously till effect and maintenance with halothane and oxygen mixture was found to be optimum for the reduction of Colles fracture. Craniocaudal and mediolateral radiographic views of radius-ulna were taken at different intervals and clinical parameters like heart rate, rectal temperature, respiration rate, inflammatory swelling and serum enzyme activity were used in the assessment of fracture healing in animals of all the groups. Proper postoperative care was instructed to the owners and specific individual postoperative care for animals of group I and III were provided regularly to avoid pin-tract infection. The ESF and CESF were removed between 4th and 6th week, implant of T-plate was left permanently at the site of fracture and the POP cast was removed after radiographic evaluation after 3rd week. The quality of physical rehabilitation of these patients was considered for the evaluations of the different fixation methods. In this study the ESF was evaluated as first choice followed by T-plating and Ilizarov ring fixator, respectively, for the management of Colles fracture. Plaster of Paris has been evaluated as inappropriate method for the management of Colles fracture in small to medium size of dogs.
  • ThesisItemOpen Access
    Biomechanical evaluation of repair modalities for bovine metacarpal/tibial fracture
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2006-06) Gupta, Ashutosh Kumar; Das, Arup Kumar
    There was two parts of this study: First, in vitro evaluation of transfixation cast (PW:TFC) and rain water pipe cast (PVC:RWPC) for their load bearing capacity was carried out. Thereafter clinical evaluation of those casts was undertaken in twelve bovine fracture cases (Group- I: 6 cases of tibial fracture treated with PW:TFC) and (Group- II: 6 cases of metacarpal fracture treated with PVC:RWPC). Clinical relevance of those casts like ease of application, conformability and strength development was also evaluated. Compressive stress of the transfixation cast (PW:TFC) and rain water pipe cast (PVC:RWPC) were found to be (Mean ±SE) 3.482 ±0.182 N/mm2 and 12.599 ±0.619 N/mm2, respectively.. Bending stress of the transfixation cast (PW:TFC) and rain water pipe cast (PVC:RWPC) were found to be (Mean ±SE) 5.534 ±0.233 N/mm2 and (Mean ±SE) 3.013 ±0.078 N/mm2. PVC:RWPC found superior than PW:TFC as per as radiolucency test is concern. All the clinical parameters like heart rate, rectal temperature, respiration rate and inflammatory signs of pain and swelling were also recorded before and after the fracture fixation. The radiographs were taken to evaluate the success of fracture reduction and fixation. Serum alkaline phosphatase activity was measured at different intervals during the convalescent period of bone healing.
  • ThesisItemOpen Access
    Studies on diagnosis and treatment of septic tenosynovitis in buffaloes
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2005-05) Sarvesh Kumar; Sharma, V.K.
    The present study was conducted on ten clinical cases suffering with tenosynovitis to assess the effectiveness of medical and surgical treatment. The animals were divided randomly into two groups. Animals of group A were treated with systemic and intrathecal injections of gentamicin after proper aspiration of the synovial fluid while animals of group B were treated with systemic and intrathecal injections of gentamicin along with debridement and irrigation of affected site with normal saline mixed with gentamicin through a indwelling surgical drain placed in the tendon sheath. The diagnosis of the disease and determination of the efficacy of therapeutic regimens was done on the basis of clinical signs, haematology, synovial fluid analysis, microbiological studies faciagraphy and ultrasonography for a period of 60 days. Clinical observation of clinical cases revealed a significantly increased rectal temperature, lameness score, swelling and severe pain at the affected site which reduced gradually after institution of therapy which was early and complete in group A. The haematological findings did not reflect any significant change except an increase in the neutrophil and a decrease in lymphocyte before treatment which improved after initiation of treatment. Before treatment the altered colour and consistency of synovial fluid was recorded with high quantity of flocculant materials which changes to normal after treatment but earlier in group A. During pre-treatment phase significantly lower value of MPQ, lymphocyte, glucose and albumin and globulin ratio was recorded in all the animals which gradually increased during post-treatment periods. A significantly higher values of total leukocyte count and neutrophil count was observed in all the animals before treatment which reduced after treatment but earlier in group A. A significantly high level of synovial fluid aspartate and alanine amino transferase, alkaline, and acid phosphatase, lactate dehydrogenase and total protein was observed before treatment in all the animals which reduced gradually after treatment. No significant difference was observed between the groups for any blood and synovial fluid parameter studies. On microbial isolation coagulase positive Staphylococcus sp. was found in all the 10 samples along with Streptococcus sp. and E. coli. which showed a maximum sensitivity for gentamicin. On faciagraphy thickened flexor tendon sheath along with adhesions between tendon sheath to underlying tissues and skin was observed which reduced in both the groups as the treatment advances but earlier in group A animals. Before treatment ultrasonogram revealed distension of the digital flexor tendon sheath evidenced by presence of anechoic zone and increased echogenicity of the superficial and deep digital flexor tendon and suspensory ligament. Ultrasonogram taken after initiation of treatment demonstrated an increase echogenicity of soft tissue and no demarcation between various layers of soft tissues during initial stage. These change were more severe in group B animals. The ultrasonograms depicted almost normal appearance of soft tissues on 45th and 60th post-treatment day in group A and group B respectively. The results of the present study suggests that both the therapeutic regimens are effective for the treatment of septic tenosynovitis. However, medical treatment combined with periodic aspiration of synovial effusion was found better over the surgical treatment combined with indwelling catheterization. Medical treatment and aspiration of fluid was found easy to use and initiated less adhesion formation between tendon and tendon sheath. Whereas, surgical debridement and indwelling catheterization of tendon sheath produced marked adhesion between tendon and tendon sheath which restricted normal tendon function.
  • ThesisItemOpen Access
    Isolation and propagation of muscle-derived mesenchymal cells and assessment of their regenerative potential in skeletal muscle injuries in mice
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2019-08) Godiyal, Akanksha; Kandpal, Manjul
    The present study was conducted on 24 clinically healthy Swiss albino mice (8-10 weeks old) of either sex, weighing 25-35 gm. The animals were divided into three groups viz. group A, B and C, having 8 animals in each. In all the groups, the gastrocnemius muscle was injured by surgical resection of the muscle. After creating muscle injury, PBS was injected in the mice of group A (control group) on day 1 and 5. In the mice of group B, MDSCs were injected in the injured muscle on day 1 and 5. While in the mice of group C, MDSCs were injected in the injured muscle on day 5 and 10. Muscle-derived mesenchymal cells were isolated by modified preplate method and cultured in proliferation media and incubated at 37 °C in a humidified 5% CO2 incubator. When the cells reached 70-80 % confluency, they were harvested using 0.25% trypsin-EDTA and cells were implanted at the site of injury in animals of group B and C. The regenerative potential of MDSCs for repair of the injured muscle was assessed by the evaluation of physical parameters, physiological parameters, wound condition, biochemical parameters, histopathological studies and free wire hanging test at different time intervals. Also, gene expression profiling of mVEGF was done for the evaluation of muscle regeneration via angiogenesis on day 7 and 15 after creation of muscle injury wound. On the basis of parameters observed in the present study, early and better healing of injured muscle was revealed in the mice of group B. There was early reduction in swelling, exudation, warmth and pain at the repaired site in the mice of group B. The level of enzymes CK, LDH, AST and AST was decreased significantly in the mice of group B. Also, the score of free wire hanging test was highest in the mice of group B as compared to the mice of group A and C indicating complete regeneration of the injured muscle. Histopathological observations revealed the presence of well organized, polygonal shaped regenerated myofibers having peripherally arranged nucleus in the mice of group B. Gene expression analysis showed upregulation of the gene mVEGF in group B as compared to control group. Results concluded that muscle-derived mesenchymal cells can be isolated by modified preplate method, cultured in-vitro and could be used without any scaffold for regeneration of injured skeletal muscle. Therefore, the current study confirmed that muscle-derived mesenchymal cells may be used for early, better and complete muscle regeneration in clinical cases of muscle injuries.
  • ThesisItemOpen Access
    Studies on the chemotherapeutic effects of Docetaxel and gene expression during regression of mammary tumour in canine
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2019-08) Upadhyay, Prachi; Jadon, N.S.
    Sixteen adult dogs suffering from canine mammary tumours used in this study were divided randomly into two groups having equal number of dogs (Group I and Group II). Patients of group I were subjected to administration of docetaxel (@30mg/m2 weekly four consecutive cycles) and patients of Group II were subjected to surgical excision of tumoral growth followed by chemotherapy with docetaxel (@30mg/m2 weekly four consecutive cycles). The therapeutic efficacy was determined by observing various parameters clinical (physical appearance and gross regression), radiological assessment, ultrasonographic screening, haematological (haemoglobin, total erythrocyte count, total leucocyte count and differential leucocyte count), biochemical (aspartate amino transferase, alanine amino transferase, serum creatinine and serum urea nitrogen) histopathological and gene expression profiling of EGFR to assess the fold change in its expression as result of treatment modality via RT-PCR analysis. The rectal temperature, heart rate and respiration rate showed non-significant changes at various time intervals in both the groups. Haemoglobin levels decreased non-significantly, total erythrocyte count and platelets varied non-significantly in both the groups. Neutrophil count revealed significant decrease in both the groups, whereas significant increase in lymphocyte increased significantly in both the groups and significant increase was observed in group II as compared to group I. Biochemical study revealed significant increase in levels of AST, BUN and serum creatinine within group II further, significant increase was also observed in group II as compared to group I. istopathologically, five (31.25%) tumours appeared to be benign while eleven (68.75%) tumours were malignant. On ultrasonographical study, no difference in regularity of tumour shape and margins, echotexture and shadowing was observed among benign and malignant tumours, tumour echogenicity was homogenous in benign tumours and posterior enhancement was evident in malignant ones. Lateral and ventrodorsal radiographs manifested lung metastsis in 10 cases however, three cases out of eight in group I and one case out of eight in group II revealed slight lung clearence on day 28. Clinical response rate was responders 62.5% and non-responders 37.5% in group I. In group II, complete response with no reoccurrence was observed in five cases (62.5%) and three cases showed reoccurrence, these patients had a tendency towards better survival rates and prolongation of life as compared to group I. Gene expression profiling revealed that EGFR receptor was comparatively more down-regulated in patients of group II subjected to surgical resection of canine mammary tumours followed by chemotherapy as compared to patients of group I which were subjected to docetaxel therapy. On the basis of above mentioned parameters it was concluded that the combination therapy had better response rate, survival rates and more down-regulation of EGFR gene involved in tumour invasion and metastasis. Combination of surgery and chemotherapy with docetaxel may be used safely by field veterinarians under proper observation for the treatment of mammary tumours in canines.
  • ThesisItemOpen Access
    Anaesthetic evaluation of various combinations of acepromazine, butorphanol and propofol in dogs
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2019-07) Rohit Prabhat; Kandpal, Manjul
    Eighteen adult dogs (requiring various clinical procedures) used in this study were divided randomly into three groups (A, B and C). All the dogs were premedicated with injection atropine sulphate at the dose rate of 0.04mg/kg body weight I/M in all the groups. Thereafter, acepromazine at the dose rate of 0.05mg/kg body weight I/M, butorphanol at the dose rate of 0.4mg/kg I/M and combination of acepromazine (at the rate of 0.05mg/kg body weight I/M) and butorphanol (at the rate of 0.04mg/kg body weight I/M), were administered in the group-A, -B and -C, respectively. The general anaesthesia using propofol in the group-A, -B and -C were found to be, 6.13±2.50mg/kg body weight, 4.84±1.97 mg/kg body weight and 3.49±1.42mg/kg body weight, respectively on intravenous administration. Maintenance of propofol with repetitive administration of established dose was done on the basis of response. The effectiveness of anaesthesia was evaluated by observing various clinical (Induction time, duration of anaesthesia, muscle relaxation, recovery time, required doses of induction agent, physiological (rectal temperature, heart rate, respiration rate, blood pressure, SpO2, electrocardiography), haematological (haemoglobin, total erythrocyte count, total leucocyte count, differential leucocyte count, packed cell volume, and biochemical (serum glucose, total protein, serum urea nitrogen, serum creatinine, serum bilirubin, alanine amino transferase and aspartate amino transferase) parameters before and after administration of anaesthesia. Group-C showed a quicker induction, better analgesia and muscle relaxation as compared to the other groups. Heart rate and respiratory rate increased significantly in group-A after anaesthesia. In group-C mean arterial blood pressure was increased as compared to other groups. In all the groups haematological parameters maintained their values within the normal range significantly. Serum glucose and total protein values altered significantly within their normal range in all the groups but total protein was somewhat higher in group-A. The creatinine and blood urea nitrogen vary significantly within the normal range. AST, ALT and total bilirubin level was significantly reduced transiently and then maintained within the normal range in all the groups. On the basis of clinicophysiological and haematobiochemical observation, all the anaesthetic combination were found suitable and effective in canine general surgery. Propofol with its smooth induction, short duration of action, early recovery and good compatibility with acepromazine and butorphanol, either alone or in combination, was found to be an effective general anaesthetic. Being a neuroleptanalgesia, acepromazine and butorphanol with propofol (group-C) was found suitable for surgeries demanding pain salvage for long duration.
  • ThesisItemOpen Access
    Studies on biocompatibility and biodegradability of magnesium based orthopaedic bone implants in avian model
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2019-06) Abhishek, M.S.; Das, Arup Kumar
    The present study was conducted in 18 adult Uttara-fowls of 8-10 months of either sex, divided into three groups with six birds each, for intramedullary insertion of Mg and Mg-apatite orthopaedic bone spacers with the objective of finding their biodegradability and biocompatibility for the period of 180 days. In first, second and third group, plain Magnesium (Mg), Mg with five per cent Hydroxyapatite (HA) and Mg with 15 per cent HA containing implants, were surgically inserted in intramedullary space of humerus, respectively. The anaesthetic regimen with atropine sulphate premedication and induction of ketamine anaesthesia was pursued. For radiography medio-lateral and leading edge (Hanging-drop positioning technique) views for humerus of the birds were taken on scheduled intervals (immediate postoperative, 1st week, 2nd week, 3rd week, 4th week, 6th week, 8th week,10th week, 12th week, 15th week, 18th week, 21st week and 24th week) and clinical parameters like heart rate, cloacal temperature, surgical duration, flight test, wing dropping test, histological evaluation and serum magnesium, calcium and phosphorous estimation were assessed to evaluate biodegradability and biocompatibility of implant material. Similar postoperative treatment and care were given to every bird during surgical convalescence. At the end of the study all the birds were euthanized with intravenous injection of thiopentone sodium as recommended by The Animal Welfare Board of India. Initiation of biodegradation was discernible in radiographs in birds of Group-I on 1st-2nd week (11th day); in Group-II on 3rd week (17th day); and Group-III on 1st week (6th day). In this study the biodegradable magnesium based orthopaedic bone implants were evaluated as the best choice for the avian fracture management. From this study following conclusions can be made (i) all Mg based metallic implants are biocompatible and biodegradable (ii) concentration of HA relates directly in the biodegradation of the Mg-HA matrix implant.