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Govind Ballabh Pant University of Agriculture and Technology, Pantnagar

After independence, development of the rural sector was considered the primary concern of the Government of India. In 1949, with the appointment of the Radhakrishnan University Education Commission, imparting of agricultural education through the setting up of rural universities became the focal point. Later, in 1954 an Indo-American team led by Dr. K.R. Damle, the Vice-President of ICAR, was constituted that arrived at the idea of establishing a Rural University on the land-grant pattern of USA. As a consequence a contract between the Government of India, the Technical Cooperation Mission and some land-grant universities of USA, was signed to promote agricultural education in the country. The US universities included the universities of Tennessee, the Ohio State University, the Kansas State University, The University of Illinois, the Pennsylvania State University and the University of Missouri. The task of assisting Uttar Pradesh in establishing an agricultural university was assigned to the University of Illinois which signed a contract in 1959 to establish an agricultural University in the State. Dean, H.W. Hannah, of the University of Illinois prepared a blueprint for a Rural University to be set up at the Tarai State Farm in the district Nainital, UP. In the initial stage the University of Illinois also offered the services of its scientists and teachers. Thus, in 1960, the first agricultural university of India, UP Agricultural University, came into being by an Act of legislation, UP Act XI-V of 1958. The Act was later amended under UP Universities Re-enactment and Amendment Act 1972 and the University was rechristened as Govind Ballabh Pant University of Agriculture and Technology keeping in view the contributions of Pt. Govind Ballabh Pant, the then Chief Minister of UP. The University was dedicated to the Nation by the first Prime Minister of India Pt Jawaharlal Nehru on 17 November 1960. The G.B. Pant University is a symbol of successful partnership between India and the United States. The establishment of this university brought about a revolution in agricultural education, research and extension. It paved the way for setting up of 31 other agricultural universities in the country.

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  • ThesisItemOpen Access
    Immunopathological effects of kitazin, an organophosphorous pesticide in broilers
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2009-05) Kohila, P.; Thathoo, A.K.
    The present experiment was carried out to assess the acute and sub acute toxic effects of Kitazin, an organophosphorous pesticide in broiler chicken. To assess the acute toxic effects of Kitazin, a total of 48 day old broiler chicks were randomly divided in four groups of 12 birds each. After one week of acclimatization period, a single oral dose of Kitazin was administered @ 300mg, 600mg and 900 mg/ Kg body weight to group 2 (T1), group 3 (T2) and group 4 (T3) respectively. To assess the sub acute toxic effects of Kitazin, a total of 48 day old broiler chicks were randomly divided in four groups of 12 birds each. After one week of acclimatization period, Kitazin was incorporated in the feed @ 100 ppm, 200 ppm and 400 ppm to group 2 (T1), group 3 (T2) and group 4 (T3) respectively for a period of 6 weeks. In both the studies the group 1 birds served as control (C). Blood and serum samples were collected once in a week in acute toxicity study, and once in two weeks interval in sub acute toxicity study to assess the haematological and biochemical parameters respectively. In acute study, the birds were sacrificed at the end of 14th and 21st day of age, to study the pathomorphology of organs. In subacute study, the birds were sacrificed on 49th day of age. Acute toxicity of Kitazin produced typical neurological signs such as ataxia, in coordination, drooping of wings, tremors, convulsions and death. The average body weights of experimental birds measured at once in 14 days interval revealed a significant decrease in Kitazin treated birds in both acute and sub acute toxicity study. Effects of Kitazin on the haematological parameters were significantly decreased haemoglobin, PCV and TEC values in both acute and sub acute toxicity study. A significant decrease in TLC, lymphocyte count, MCV and MCH values were also observed. The results of the biochemical studies had a significant increase in serum glucose, total cholesterol, SGOT and creatinine values in both the studies. A significant increase in SGPT and BUN values were observed in sub acute toxicity study. The levels of total proteins, albumin, globulin and A/G ratio were significantly decreased in both the studies. Results of Lymphocyte Stimulation Test (LST) showed a significant decrease in mean delta OD values of both Con-A and LPS stimulated lymphocyte cultures from treatment groups in comparison to control group.A significant reduction in the organ/body weight ratio was observed for liver, spleen and bursa in both the studies. Grossly, congestion of all organs was noticed. Histopathological examination of liver showed hyperemia, mononuclear cell inifiltration and hepatocytes undergoing various stages of degeneration. Kidney showed glomerular nephritis, nephrosis and haemorrhages. Desquamation of bronchial epithelium, edema, emphysema and congestion were observed in the lungs. Degenerative and necrotic changes were observed in the spleen and bursa. The lesions in the brain were congestion, perivascular cuffing, chromatolysis, neuronophagia and extensive spongiform changes. From the findings of the present study, it may be concluded that, Kitazin has adverse effects on the general health, body weight and immune status of the birds and these effects are dependent on its dose and duration of exposure.
  • ThesisItemOpen Access
    Clinicopathological studies on effects of brass industry effluent in animals
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2007-01) Manjunatha, K.N.; Thathoo, A.K.
    The present experiment was conducted to study the clinicopathological effects of Brass industry effluent in animals. For this, various samples (effluent, soil and fodder) were collected around the brass industries located in Moradabad and subjected to physico-chemical analysis. Toxicity of the effluent was studied by using mice as an experimental animal model. The physico-chemical analysis of effluent samples showed significantly (P<0.05) increased levels of COD, BOD, TS, TDS, TSS, and heavy metals as compared to control. There was significantly higher levels of metals in soil (Zn, Cu, Cd and Pb) and in fodder (Zn, Cu, Mn, Fe, Cd, and Pb) samples that were collected from and around the industries compared to the control site. Animal experimentation revealed significant effects of the effluent on body and organ weights, hematological and biochemical parameters. There was significant decrease in body and liver weight as compared to control. Total erythrocyte count was increased significantly, whereas total leukocyte count decreased significantly as compare to the control. There was decrease in percent monocyte (%) and percent increase in the neutrophils as compared to the control. On serum biochemical examination it was evident that there was significantly (P<0.05) higher levels of BUN, Creatinine, AST and ALT, where as significant decrease in total protein and albumin levels as compared to the control. The levels of zinc, cadmium and lead in serum and liver samples of mice exposed to effluent were significantly (P<0.05) increased as compared to the control. The histopathological examination of various organs revealed, congestion, edema, adhesion of glomerulus to the Bowman‟s capsule, interstitial nephritis, extensive degeneration of tubular epithelium, proteinacious casts, atrophy of glomerulus, glomerular hemorrhages and necrosis in kidneys. Liver showed congestion, edema, vacuolar degeneration and dilatation of sinusoids. Congestion hemorrhages and focal areas of necrosis were seen in spleen. Lungs showed congestion, edema, emphysema, interstitial pneumonia, bronchopneumonia and focal areas of accumulation of mononuclear cells around bronchus. Testes showed mild congestion, edema, degeneration, detachment of cells from basement membrane, impaired spermatogenesis and atrophy of seminiferous tubules. In the brain, congestion, edema, perivascular cuffing, chromatolysis, neuronophagia and extensive vacuolations were observed. Based on above findings, it may be concluded that the effluent from brass industries have higher levels of COD, BOD, TS, TDS, TSS and heavy metals. Effluent discharged from these industries has increased the heavy metal concentration in and around the areas of these industries (soil and fodder). From the animal experiment, it is suggested that the brass industry effluent causes significant chronic health effects on animals.
  • ThesisItemOpen Access
    Clinicopathological studies of chronic endosulfan and chlorpyriphos intoxication in poultry
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2005-06) Singh, Atul Kumar; Agrawal, D.K.
    The present investigation was carried out to study the prolonged, toxic effect of endosulfan and chlorpyriphos in poultry using “No Observable Adverse Effect Level”. Hundred 2-week-old chicks (divided into 3 groups) were used for a period of 2 months. The birds of group I given normal basal ration served as control. Group II birds were fed endosulfan (30 ppm) while group III birds were given chlorpyriphos (0.3 ppm) treated feed. Five birds from each group were taken after every 10 days interval for collection of blood and serum samples. Tissue samples from liver, spleen, thymus and bursa of Fabricius were collected for Histopathological examination after conducting the post mortem. In addition, liver, kidney and muscles were taken to study the level of pesticide residues in these organs. In the present investigation, no significant change in Hb and PCV occurred in any group. Leucopenia and lymphopenia recorded in present study. A decrease in total serum protein and albumin content in the pesticides treated birds due to hepatic dysfunction. Histopathological examination of organs collected showed mild to severe damage with increase in duration. From the present study, it may be concluded that even NOAEL dose of endosulfan and chlorpyriphos can cause hemato-biochemical and pathomorphological changes, which may be responsible for immune competence, vaccinal failure and mortality among birds.
  • ThesisItemOpen Access
    Pathology of zinc nanoparticles in wistar rats
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2018-07) Pathak, Abhivyakti; Agarwal, Seema
    The present study was carried out for a period of 90 days to study the pathology of nano zinc in rats. For this study, a total of 35 rats of six week age were divided randomly into two groups of 20 rats in Group I (control) and 15 rats in group II (treated). In treated group rats were given nano zinc particles with NOAEL dose of nano zinc oxide 31.25 mg/kg body weight of rat for a period of 90 days, RO water was provided to both control and treated groups. In this study, clinical and behavioural signs were observed daily in the morning and evening. Body weight was studied at 15 days interval taking samples from 5 rats from each group. Besides, hematological, biochemical and histopathological studies, relative organ weight and humoral immune response was performed at 30 days interval from 5 rats from each group. Clinical and behavioural signs like decreased response for feed and dull behavior were observed in treated group. Reduction in parameters like body weight and relative organ weight of thymus, spleen and liver was observed as compared to control group. Hematological parameters like hemoglobin (Hb), mean corpuscular hemoglobin (MCH) and mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), total leucocyte count (TLC), absolute lymphocyte count (ALC) and lymphocyte count showed decrease in values as compared to control. Biochemical parameters revealed the significant increase in the total serum protein, total serum albumin, total serum globulin, serum albumin globulin ratio, blood urea nitrogen (BUN), serum creatinine value, serum Aspartate amino transaminases (AST) value and serum Alanine amino transaminases (ALT) value in nano zinc treated group. The results in this study revealed increase in humoral immune response as measured by HI test. In treated group, grossly liver showed discoloration and petechiation and lungs showed congestion and consolidation in treated group. Histopathological lesions were observed in various organs. In liver, lesions comprised of congestion in blood vessels, degeneration and necrosis in hepatocytes with infiltration of leucocytes. Kidney in treated group, revealed interstitial haemorrhage, degenerative and necrotic changes in tubular epithelium, leucocytic infiltration in glomeruli and interstitial spaces and detachment of tubular epithelium from basement membrane. Heart showed congestion. Lung revealed congestion of blood vessels, thickening of alveolar septa, emphysema and atelectasis at places, infiltration of leucocytic cells at many places in lung parenchyma. Brain of treated group showed mild congestion. Intestinal lesions comprised of sloughing of villus epithelium, disrupted villi, and hyperplasia of goblet cells with infiltration of leucocytic cells in lamina propria. Histopathological finding of spleen showed degeneration and necrosis of lymphoid cells leading to depletion of lymphoid tissue. Thymus showed mild hemorrhage and depletion of lymphoid tissue. However, no microscopical lesions were observed in control group. Based on the above findings, it was concluded that nano zinc causes ill effects on the health status of rats even at NOAEL dose. It induces structural and functional alteration in various organs of the body and thus causes health hazards. It is suggested that further studies should be carried out in different animal models using varied doses and increased duration to exactly find out the pathological alterations in order to take further therapeutic and preventive measures.
  • ThesisItemOpen Access
    Pathology of nano alumina in chickens
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2017-07) Kuntal, Naresh Singh; Agarwal, Seema
    The present study was carried out for a period of 90 days to study the pathology of nanoalumina in chickens. 40 chicks of two week age were divided randomly into two groups of 20 birds each viz. Group I (control) and Group II (treated). In treated group nanoalumina used as aluminium oxide (Boehmite), was given orally in standard recommended feed at the rate of 200 ppm. RO water was provided to both control and treated groups. In this study, clinical and behavioural signs were observed daily in the morning. Body weight and hematolgical parameters were studied at 15 days interval taking samples from 10 birds from each group. Besides, humoral immune response was performed at 30 days interval taking samples from 10 birds from each group. Histopathological, absolute organ weight, relative organ weight and cell mediated immunological studies were performed at the end of experiment i.e. 90th DPT. Clinical and behavioural signs like increased activeness and aggressiveness or fighting behaviour were observed in treated group. Reduction in parameters like body weight, relative organ weight and absolute organ weight was observed as compared to control group. However, the change was significant only in the reduction of the absolute organ weight of the thymus. Hematological parameters like hemoglobin (Hb), packed cell volume (PCV), total erythrocyte count (TEC), total leucocyte count (TLC), absolute lymphocyte count (ALC) and absolute heterophil count (AHC) showed decrease in values as compared to control. However, significant increase observed in hemoglobin, packed cell volume and total erythrocyte count. There was decrease in values of mean corpuscular hemoglobin (MCH) and mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCHC), lymphocyte count and heterophil count as compared to control group. However, significant decrease observed in means corpuscular hemoglobin and mean corpuscular volume. The results in this study revealed increase in humoral immune response and cell mediated immune response but the results are not significant statistically. In treated group, grossly liver, lungs, spleen, kidney and intestine showed congestion, while brain had echymotic hemorrhage in treated group. However, no observable gross lesions were observed in control group. Histopathological lesions were observed in various organs. In liver, lesions comprised of fatty changes, congestion in blood vessels, degeneration and necrosis in hepatocytes with infiltration of leucocytes. Kidney in treated group, revealed interstitial haemorrhage, degenerative and necrotic changes in tubular epithelium, leucocytic infiltration in glomeruli and interstitial spaces and detachment of tubular epithelium from basement membrane. Heart showed congestion along with degenerative changes in myocardial muscle fibre. Lung revealed congestion of blood vessels, thickening of alveolar septa, hemorrhage, emphysema and atalectesis at places, infiltration of leucocytic cells at many places in lung parenchyma. Brain of treated group showed hyperimic blood vessels, vacuolation and degenerative changes in cell body. Intestinal lesions comprised of sloughing of villus epithelium, disrupted villi, and fusion of villi with infiltration of leucocytic cells. Testis revealed detachment of seminiferous epithelium from basement membrane and distortion of seminiferous tubules. Proventriculus showed lymphofollicular reaction in submucosa. Skeletal muscles comprised of necrotic changes with infiltration of leucocytes. Histopathological finding of spleen showed degeneration and necrosis of lymphoid cells leading to depletion of lymphoid tissue. Thymus showed mild hemorrhage and depletion of lymphoid tissue. Bursa of Fabricius revealed depletion of lymphoid tissue. However, no microscopical lesions were observed in control group. Based on the above findings, it is concluded that nanoalumina causes ill effects on the health status of chickens even at maximum tolerable level. It induces structural and functional alteration in various organs of the body and thus causes health hazards leading losses in terms of production. It is suggested that further studies should be carried out in different animal models using varied doses and increased duration to exactly find out the pathological alterations.