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Subject: Veterinary Pharmacology and Toxicology × Author: HARISHA, C. B. × Start date: 2020 ×
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    ThesisItemOpen Access
    PHARMACOLOGICAL AND TOXICOLOGICAL STUDIES OF AGERATUM CONYZOIDES IN RATS
    (KARNATAKA VETERINARY, ANIMAL AND FISHERIES SCIENCES UNIVERSITY, BIDAR, 2022) HARISHA, C. B.; SHRIDHAR, N. B.
    The study was taken up to evaluate the pharmacological and toxicological property of Ageratum conyzoides (A. conyzoides) plant extract in rats. Phytochemical analysis revealed the presence of carbohydrates, proteins, saponins, alkaloids, flavonoids, phenolic compounds, phytosterols and triterpenoids. The in vivo antiinflammatory property of the plant extract was studied using carrageenan induced paw oedema method and the extract at the doses of 1000 and 1500 mg/kg and was having significant anti-inflammatory activity by reducing the paw edema by 33.77 % and 40.26 % respectively compared to standard drug meloxicam which was 46.75 %. In vivo analgesic activity was conducted by using acetic acid induced writhing model and the extract at the doses 1000 and 1500 mg/kg exhibited significant analgesic activity by reducing the writhing response by 35.09 % and 41.22 % respectively compared to standard drug meloxicam which was 48.33%. Acute oral and repeated dose 28-day oral toxicity studies of methanol extract was carried out in Wistar albino rats as per the OECD guidelines 423 and 407 respectively. In sub-acute oral toxicity study, dose levels of 500, 1000 and 1500 mg/kg were administered daily for 28 days and compared with the control rats. In both toxicity studies, no mortality and toxicity signs were observed. The MTD value was found to be more than 5000 mg/kg. The treatment groups did show changes in haematological and biochemical parameters which were evident by histopathological changes in different organs. The plant aerial part extract exhibited substantial anti-inflammatory and analgesic properties, which can be used to investigate the plant's therapeutic efficacy. Key words: Ageratum conyzoides, Phytochemical analysis, Anti-inflammatory activity, Toxicity, Wistar albino rats.