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Theses (PG)

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20205
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Subject: Veterinary Pathology × End date: 2020 × Start date: 2020 × Type: Thesis ×
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    ThesisItemOpen Access
    STUDIES ON INDUCED DIABETES IN RATS WITH SPECIAL EMPHASIS ON COMBINED EFFICACY OF Gymnema sylvestre AND Eugenia jambolana
    (KARNATAKA VETERINARY ANIMAL FISHERIES SCIENCES UNIVERSITY., 2020-02) NAGABHUSHAN, C; Dr. SUGUNA RAO
    The present study was taken up to evaluate the combined antidiabetic effect of Gymnema sylvestre and Eugenia jambolana along with glibenclamide in streptozotocin induced diabetic rats for a period of 45 days. The various groups in this study included normal control (Group I), diabetic control (Group II), diabetic rats treated with glibenclamide (Group III), diabetic rats treated with a combination of Gymnema sylvestre and Eugenia jambolana at half dose (Group IV), diabetic rats treated with a combination of Gymnema sylvestre and Eugenia jambolana at full dose (Group V), diabetic rats treated with a combination of Gymnema sylvestre and Eugenia jambolana along with glibenclamide at half dose (Group VI) respectively. There was significant difference in physiological, biochemical and pathomorphological parameters of diabetic rats when compared to normal control rats. The alleviation of diabetic effects and its complications induced
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    ThesisItemOpen Access
    STUDY ON THE EVALUATION OF DIAGNOSTIC METHODS OF ANIMAL RABIES USING BRAIN TISSUES COLLECTED BY DIFFERENT APPROACHES
    (KARNATAKA VETERINARY, ANIMAL AND FISHERIES SCIENCES UNIVERSITY, BIDAR, 2020-08) MOHAMED GHOUSE, H; Dr. M. L. SATYANARAYANA
    A total of 51 brain Samples (cerebellum and brain stem) were collected from rabies suspected animals that were received for rabies diagnosis at Department of veterinary pathology, Veterinary college, Bangalore. Brain samples collected by foramen magnum approach using simple instruments viz., Artificial Insemination (AI) sheath and also collected from conventional skull open method. The LFA, DFA and dRIT tests were conducted and comparative evaluation of all three tests was done on samples collected from both the methods. Out of 51 samples tested, 41 were positive and 10 were negative for rabies by LFA, DFA and dRIT tests. There was 100 per cent correlation between the LFA, DFA and
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    ThesisItemOpen Access
    STUDIES ON INDUCED DIABETES IN RATS WITH SPECIAL EMPHASIS ON COMBINED EFFICACY OF Gymnema sylvestre AND Momordica charantia EXTRACTS
    (KARNATAKA VETERINARY, ANIMAL AND FISHERIES SCIENCES UNIVERSITY, BIDAR, 2020-07) KAVYASHREE, T.L; Dr. M.L. SATYANARAYANA
    The present study was conducted in diabetes induced rats with special emphasis on efficacy of combined herbal extracts. Gymnema sylvestre and Momordica charantia were used at the dose of 200 mg/kg b.w each (100per cent) and Gymnema sylvestre + Momordica charantia at the dose rate of 100 mg/kg b.w each (50per cent) and Glibenclamide at the dose rate of 300 µg/kg b.w (50per cent) were administered in combination and compared with an oral hypoglycaemic drug, Glibenclamide, for a period of 45 days. There was a significant difference in various parameters like body weight, serum glucose, serum cholesterol, serum triglycerides, ALT, AST, haemoglobin, RBC count, WBC count, platelets count and antioxidant enzymes (SOD, GPx and CAT) in diabetic rats as compared to normal control rats. The partial alleviation of diabetic effects was observed in all combination of treatments in the present study
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    ThesisItemOpen Access
    STUDIES ON INDUCED DIABETES IN RATS WITH SPECIAL EMPHASIS ON EFFICACY OF COMBINED HERBAL EXTRACT
    (KARNATAKA VETERINARY, ANIMAL AND FOISHERIE'S SCIENCES UNIVERSITY, BIDAR, 2020-07) RASHMI WALI; Dr. M.L. SATYANARAYANA
    The present study was undertaken to evaluate the efficacy of combined herbal extract along with glibenclamide in streptozotocin induced diabetic rats for a period of 45 days. The various groups in this study included normal control (Group I), diabetic control (Group II), diabetic rats treated with glibenclamide (Group III), diabetic rats treated with combined herbal extract (Group IV) and combination of combined herbal extract and glibenclamide (Group V). There was significant variation in biochemical and pathomorphological parameters (antioxidant assay and histopathology) in diabetic rats when compared to normal control rats. The alleviation of the diabetes and its complications induced by streptozotocin was obseved in all the treatment groups with variable degree of improvement. Combination of combined herbal extract and glibenclamide was effective in alleviating streptozotocin induced diabetes and was comparable with glibenclamide. Combination of combined herbal extract (50%) and glibenclamide (50%) showed better improvement compared to combined herbal extract alone but statistically no significant synergetic action was observed. However, synergistic effect was noticed in combination of combined herbal extract and glibenclamide. Key words: Diabetes, combined herbal extract, glibenclamide, streptozotocin
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    ThesisItemOpen Access
    STUDIES ON INDUCED DIABETES IN RATS WITH SPECIAL EMPHASIS ON COMBINED EFFICACY OF GYMNEMA SYLVESTRE AND SWERTIA CHIRAYITA EXTRACTS
    (KARNATAKA VETERINARY, ANIMAL AND FOISHERIE'S SCIENCES UNIVERSITY, BIDAR, 2020-01) BHARATH KUMAR, K.; Dr. SUGUNA RAO
    The present study was undertaken to evaluate the antidiabetic efficacy of Gymnema sylvestre and Swertia chirayita in combination with or without glibenclamide in streptozotocin induced diabetes in rats. The various groups in this study included normal control (Group I), diabetic control (Group II), diabetic rats treated with glibenclamide (Group III) at 600 μg/kg bw, diabetic rats treated with combination of Gymnema sylvestre and Swertia chirayita (Group IV) at 200 mg/kg bw each and diabetic rats treated with a combination of herbal extracts along with glibenclamide (Group V) at 100 mg/kg bw each and 300 μg/kg bw respectively. There was a significant improvement in the evaluatory parameters such as body weights, serum glucose, ALT, AST, cholesterol, triglyceride, blood parameters and hepatic antioxidant enzymes in treatment groups when compared to diabetic control. Histopathology and immunohistochemistry of pancreas also showed an improvement in the number of islet and β cells by 45th day in the treatment groups compared to diabetic control. Glibenclamide treatment substantially alleviated the effects of STZ in diabetic rats. However, the improvement was not on par with that of normal control rats. Combination of Gymnema sylvestre and Swertia chirayita with or without glibenclamide treatment only partially alleviated the STZ induced diabetic effects. Among the treatment groups, combination of herbal extract along with the glibenclamide at half dose showed better antidiabetic effect. No synergistic and no dose-dependent improvement was observed in the combination of Gymnema sylvestre and Swertia chirayita extract treatment. Combination of herbal extracts showed only mild antidiabetic effect hence cannot replace conventional anti diabetic treatment with glibenclamide. Key words: Diabetes, Gymnema sylvestre, Swertia chirayita, glibenclamide, streptozotocin, rats, immunohistochemistry