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Subject: Veterinary Medicine × End date: 2017 × Start date: 2017 × Type: Thesis ×
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    ThesisItemOpen Access
    Epidemiological and clinico-therapeutic studies on exocrine pancreatic insufficiency in dogs
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2017-07) Singh, Anand Kumar; Bhatt, Prakash
    The present investigation was undertaken to assess the prevalence of exocrine pancreatic insufficiency (EPI) in dogs and their clinicotherapeutic evaluation. Out of total 1503 dogs registered during the study period from Pantnagar and adjoining area, 961dogs were presented with gastro intestinal disorders. For the epidemiological study, 386 dogs irrespective of age, sex and breed, history of anorexia, vomition, weakness, abdominal pain, diarrhea and dehydration were examined. The dogs were preliminary declared positive for EPI on the basis of faecal trypsin test and presence of starch and neutral fat in faeces. The positive animals were further grouped for clinicotherapeutic study. A total of four groups were made with five dogs in each group. The group I dogs, received no treatment and served as healthy control. The group II dogs received pancreatin 200 mg and simethicone 40mg combination for 45 days. The group III animals received 15,000 units of USP amylase activity, 4,000 USP of lipase activity and 15,000 USP units of protease activity for 45 days. The group IV dogs received 1,00,000 armour units of enzyme activity supplied by a purified concentration which has a specific trypsin and chymotrypsin activity in the ratio of approximately six to one for 45 days. The EPI affected dogs were also administered symptomatic and supportive treatment. Haematological parameters viz. Hb, PCV, TEC, TLC, DLC, serum lipase and canine pancreatic lipase (cPL) were estimated at regular interval i.e. on 0th, 15th, 30th and 45th day of the study. The overall prevalence of EPI was found to be 0.99% on faecal analysis basis. However on serum lipase and canine pancreatic lipase activity it was found to be 0.46 and 0.40%, respectively. The clinical prevalence on faecal analysis was recorded to be 3.88% and on serum lipase and cPL basis was 1.82 and 1.56%, respectively. The maximum prevalence was observed in dogs aged 5 years and above and maximum prevalence was recorded in German shepherd dogs. All the infected group dogs exhibited significantly high level of Hb and PCV due to haemoconcentration. The leukocytic indices also showed a significant increase in leukocyte and neutrophils count as compared to healthy control. No significant change in cells of erythrocyte and leukocyte indices was recorded within groups at different intervals except neutrophil, leukocyte and lymphocyte count in treated groups. The serum lipase and cPL levels were also significantly increased in all infected groups as compared to healthy control. However, no significant difference in the number of serum lipase and cPL positive cases were observed. It can be concluded from present study that EPI has moderate clinical prevalence in and around Pantnagar region of Uttarakhand. Dogs receiving 1,00,000 armour units of enzyme activity supplied by a purified concentration which has a specific trypsin and chymotrypsin activity showed better results followed by 15,000 units of USP amylase activity, 4,000 USP of lipase activity and 15,000 USP units of protease activity.
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    ThesisItemOpen Access
    Epidemiological and clinico-therapeutic studies on exocrine pancreatic insufficiency in dogs
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2017-07) Singh, Anand Kumar; Bhatt, Prakash
    The present investigation was undertaken to assess the prevalence of exocrine pancreatic insufficiency (EPI) in dogs and their clinicotherapeutic evaluation. Out of total 1503 dogs registered during the study period from Pantnagar and adjoining area, 961dogs were presented with gastro intestinal disorders. For the epidemiological study, 386 dogs irrespective of age, sex and breed, history of anorexia, vomition, weakness, abdominal pain, diarrhea and dehydration were examined. The dogs were preliminary declared positive for EPI on the basis of faecal trypsin test and presence of starch and neutral fat in faeces. The positive animals were further grouped for clinicotherapeutic study. A total of four groups were made with five dogs in each group. The group I dogs, received no treatment and served as healthy control. The group II dogs received pancreatin 200 mg and simethicone 40mg combination for 45 days. The group III animals received 15,000 units of USP amylase activity, 4,000 USP of lipase activity and 15,000 USP units of protease activity for 45 days. The group IV dogs received 1,00,000 armour units of enzyme activity supplied by a purified concentration which has a specific trypsin and chymotrypsin activity in the ratio of approximately six to one for 45 days. The EPI affected dogs were also administered symptomatic and supportive treatment. Haematological parameters viz. Hb, PCV, TEC, TLC, DLC, serum lipase and canine pancreatic lipase (cPL) were estimated at regular interval i.e. on 0th, 15th, 30th and 45th day of the study. The overall prevalence of EPI was found to be 0.99% on faecal analysis basis. However on serum lipase and canine pancreatic lipase activity it was found to be 0.46 and 0.40%, respectively. The clinical prevalence on faecal analysis was recorded to be 3.88% and on serum lipase and cPL basis was 1.82 and 1.56%, respectively. The maximum prevalence was observed in dogs aged 5 years and above and maximum prevalence was recorded in German shepherd dogs. All the infected group dogs exhibited significantly high level of Hb and PCV due to haemoconcentration. The leukocytic indices also showed a significant increase in leukocyte and neutrophils count as compared to healthy control. No significant change in cells of erythrocyte and leukocyte indices was recorded within groups at different intervals except neutrophil, leukocyte and lymphocyte count in treated groups. The serum lipase and cPL levels were also significantly increased in all infected groups as compared to healthy control. However, no significant difference in the number of serum lipase and cPL positive cases were observed. It can be concluded from present study that EPI has moderate clinical prevalence in and around Pantnagar region of Uttarakhand. Dogs receiving 1,00,000 armour units of enzyme activity supplied by a purified concentration which has a specific trypsin and chymotrypsin activity showed better results followed by 15,000 units of USP amylase activity, 4,000 USP of lipase activity and 15,000 USP units of protease activity.
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    ThesisItemOpen Access
    Clinical and therapeutic evaluation of acidifiers in broiler chicks infected with Salmonella
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2017-07) Bijalwan, Komal; Shukla, S.K.
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    ThesisItemOpen Access
    Clinico haematobiochemical and therapeutic studies in diarrhoeic calves
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2017-07) Gupta, Neha; Rajora, V.S.
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    ThesisItemOpen Access
    Epidemiological study of caprine neonatal kid diseases and their clinical management in tarai and bhawar area (U.S. Nagar and Nainital districts) of Uttarakhand
    (G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand), 2017-06) Ilyas, Wani; Singh, J.L.
    This study was undertaken to study the epidemiology of different diseases in neonatal kids and clinico-therapeutics of Coccidiosis, Kid scours and Pneumonia in and around Pantnagar. From the prevalence study, overall morbidity rate of 52.63% and mortality rate of 21.05% was observed. Maximum morbidity was reported by Coccidiosis (39.07%) followed by pneumonia (34.0%), kid scours (17.38%), general weakness (5.84%), congenital defects (1.07%) and miscellaneous causes (2.61%). With respect to season, age and sex highest morbidity rate was found in winter season (56.30%), 1-2 month age (37.53%) group and in males (54.10%) respectively. Maximum mortality rate was highest during winter season (60.0%), 0-1 month (42.30%) and in males (56.53%). Kids suffering from Coccidiosis showed signs of anorexia, loss of body weight, inappetance, dehydration and hemorrhagic diarrhea with soiling of hindquartes. A significant decrease in temperature with increase in heart and respiration rate was found in all infected kids before treatment. A higher mean values of OPG count in feces was found in diseased kids in the range of 84000-65500. Hematological findings show a significant decrease in PCV, Hb and TEC and TLC. Biochemical analysis revealed a significant decrease in total protein, albumin, glucose, sodium, calcium and phosphorus while as a significant increase in creatinine, blood urea nitrogen, AST and ALT before treatment in all infected groups when compared with healthy group. In kid scours anorexia, diarrhea, emaciation, rough body coat and loss of body weight were the main clinical signs found during the study period with increase in temperature, heart rate and respiration rate. Hematological findings revealed a significant increase in PCV, Hb and TEC and TLC. Biochemical analysis revealed a significant decrease in total protein, albumin, glucose, sodium, calcium and phosphorus while as a significant increase in creatinine, blood urea nitrogen, AST and ALT before treatment in all infected groups when compared with healthy group. In pneumonia nasal discharge, depression, inappetance, dyspnea and coughing were the major clinical signs with increase in temperature, heart rate and respiration rate found in kids before treatment. Hematological findings revealed a significant decrease in PCV, Hb, TEC and TLC. Biochemical analysis revealed a significant decrease in total protein, albumin, glucose, sodium, calcium and phosphorus while as a significant increase in creatinine, blood urea nitrogen, AST and ALT before treatment in all infected groups when compared with healthy group. In Coccidiosis based on mean OPG count before and after treatment, Amprolium (96.12%) recorded higher comparative therapeutic efficacy followed by Sulphadimidine (93.01%) and lowest by Metronidazole (85.55%). Based on profile wise evaluation score Amoxiciilin & Sulbactum recorded a highest therapeutic score (4.655) followed by Gentamicin (4.441) and lowest by Marbofloxacin (3.955) in Kids scours. In case of Pneumonia highest therapeutic score was recorded by Amoxicillin & Clauvilinic acid (4.7) followed by Strepto-pencillin (4.182) and Cefuroxime (3.925).