Thumbnail Image

Thesis

Browse

2018 - 20202
Reset filters
Subject: Chemistry × Author: Lovepreet Kaur × Start date: 2018 × Type: Thesis ×
Reset filters

Search Results

Now showing 1 - 2 of 2
  • Thumbnail Image
    ThesisItemRestricted
    Derivatization of benzimidazole and their evaluation as antinematic agents
    (Punjab Agricultural University, Ludhiana, 2020) Lovepreet Kaur; Utreja, Divya
    2-Substituted benzimidazole derivatives were synthesized by condensation reaction of ophenylenediamine with different aryl aldehyde. N-alkylation of substituted derivatives was carried out by using different alkyl halides in the presence of phase transfer catalyst tetrabutyl ammonium hydrogen sulfate and 30% KOH as base. Characterization of synthesized derivatives was carried out using 1H NMR, 13C NMR and IR spectroscopy. The resulted compounds were also screened for their nematicidal activity against root knot nematode Meloidogyne incognita by egg hatching and mortality test. All the compounds exhibited significant nematicidal potential as compared to control. Maximum egg hatching inhibition potential and maximum mortality potential was exhibited by compound 2-(2-nitrophenyl)1H-benzimidazole (3a).
  • Thumbnail Image
    ThesisItemOpen Access
    Synthesis of novel 1,2,4-triazolosulfonamides as antifungal agents against phytopathogenic fungi
    (Punjab Agricultural University, Ludhiana, 2018) Lovepreet Kaur; Anajli
    A series of 1,2,4-triazolosulfonamides was synthesized by microwave irradiation method in excellent yield, using sulfonyl chlorides and 1,2,4-triazoles as starting materials. The products were characterized by FT-IR, 1H NMR, 13C NMR and screened for their antifungal potential against various phytopathogenic fungi viz. Alternaria alternata, Curvularia lunata, and Helminthosporium oryzae by poisoned food technique in terms of ED50 values. The synthesized compounds displayed moderate to significant activity. Among all test compounds, 4-Methyl-N-(1H-1,2,4-triazol-3-yl)benzenesulfonamide (4) and 4-Methyl-N-(4H- 1,2,4-triazol-4-yl)benzenesulfonamide (7) showed best antifungal activity against all test fungi with respective ED50 values 4.0 and 3.4 μg ml-1 against Alternaria alternata, 2.3 and 2.0 μg/ml against Curvularia lunata and 3.5 and 3.0 μg/ml against Helminthosporium oryzae, multifold lower than the standard fungicides used, Tilt and Captan. The results were rationalized on the basis of in silico analysis viz. Toxicity analysis, Docking analysis and Lipinski parameters.