Derivatization of benzimidazole and their evaluation as antinematic agents
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Date
2020
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Punjab Agricultural University, Ludhiana
Abstract
2-Substituted benzimidazole derivatives were synthesized by condensation reaction of ophenylenediamine
with different aryl aldehyde. N-alkylation of substituted derivatives was
carried out by using different alkyl halides in the presence of phase transfer catalyst tetrabutyl
ammonium hydrogen sulfate and 30% KOH as base. Characterization of synthesized
derivatives was carried out using 1H NMR, 13C NMR and IR spectroscopy. The resulted
compounds were also screened for their nematicidal activity against root knot nematode
Meloidogyne incognita by egg hatching and mortality test. All the compounds exhibited
significant nematicidal potential as compared to control. Maximum egg hatching inhibition
potential and maximum mortality potential was exhibited by compound 2-(2-nitrophenyl)1H-benzimidazole
(3a).
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Citation
Lovepreet Kaur (2020). Derivatization of benzimidazole and their evaluation as antinematic agents (Unpublished M.Sc. thesis). Punjab Agricultural University, Ludhiana, Punjab, India.