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Subject: Chemistry × Author: Amanpreet Kaur × Start date: 2021 × Thesis Type: M.Sc ×
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    Synthesis and fungicidal activity of 2-aminopyrimidine schiff bases
    (Punjab Agricultural University, Ludhiana, 2021) Amanpreet Kaur; Sharma, Sunita
    2-Aminopyrimidines represent an important class of bioactive molecules where its structural changes would lead to its versatile properties. N-Heterocyclic compound i.e. 2aminopyrimidine had wide range of applications in medicinal, material chemistry and agriculture as antifungal, antimicrobial and antibacterial agents. In the present study, a series of substituted N-benzylidine-2-aminopyrimidine compounds were synthesized by condensation reaction of 2-aminopyrimidine with substituted benzaldehydes (o-chloro, mhydroxybenzaldehyde, p-hydroxybenzaldehyde, 2,5-dimethoxybenzaldehyde, pdimethylaminobenzaldehye, syringaldehyde, o-phthaldehyde, isovanillin benzaldehyde, veratraldehyde and thiophene-2-carboxyaldehyde). The synthesised Schiff bases were characterized using UV, IR, 1H NMR and 13C spectral studies. The antifungal activity of all the synthesized Schiff bases was screened against Fusarium verticillioides, Macrophomina phaseolina, and Rhizoctonia solani using poisoned food technique. The Schiff base of pdimethylaminobenzaldehyde and 2-aminopyrimidine showed hundred percent inhibition against all the three fungi but less than carbendazim at 50 WP as its ED50 was less than all the synthesized Schiff bases. Thus, in future, this kind of pyrimidine derivatives may be used to generate better fungicides with improved fungicidal activities.