Synthesis and fungicidal activity of 2-aminopyrimidine schiff bases
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Date
2021
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Punjab Agricultural University, Ludhiana
Abstract
2-Aminopyrimidines represent an important class of bioactive molecules where its structural
changes would lead to its versatile properties. N-Heterocyclic compound i.e. 2aminopyrimidine
had wide range of applications in medicinal, material chemistry and
agriculture as antifungal, antimicrobial and antibacterial agents. In the present study, a series
of substituted N-benzylidine-2-aminopyrimidine compounds were synthesized by
condensation reaction of 2-aminopyrimidine with substituted benzaldehydes (o-chloro, mhydroxybenzaldehyde,
p-hydroxybenzaldehyde, 2,5-dimethoxybenzaldehyde, pdimethylaminobenzaldehye,
syringaldehyde, o-phthaldehyde, isovanillin benzaldehyde,
veratraldehyde and thiophene-2-carboxyaldehyde). The synthesised Schiff bases were
characterized using UV, IR, 1H NMR and 13C spectral studies. The antifungal activity of all
the synthesized Schiff bases was screened against Fusarium verticillioides, Macrophomina
phaseolina, and Rhizoctonia solani using poisoned food technique. The Schiff base of pdimethylaminobenzaldehyde
and 2-aminopyrimidine showed hundred percent inhibition
against all the three fungi but less than carbendazim at 50 WP as its ED50 was less than all the
synthesized Schiff bases. Thus, in future, this kind of pyrimidine derivatives may be used to
generate better fungicides with improved fungicidal activities.
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Amanpreet Kaur (2021). Synthesis and fungicidal activity of 2-aminopyrimidine schiff bases (Unpublished M.Sc. thesis). Punjab Agricultural University, Ludhiana, Punjab, India.