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Book Chapters (English)

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2014 - 20174
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Author: Senthilkumar, P. × Type: Book chapter ×
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    Book chapterItemOpen Access
    Development and Sustainable Release Evaluation of Enrofloxacin Solid Lipid Nanopartilces
    (2014) Senthilkumar, P.; Arivuchelvan, A.; Jagadeeswaran, A.; Subramanian, N.; Senthilkumar, C.; Mekala, P.; TANUVAS
    The study was conducted to formulate the enrofloxacin solid lipid nanoparticles (SLNs) with sustained release profile and improved pharmacological activity. The enrofloxacin SLNs were prepared using tripalmitin as lipid carrier, tween 80 and span 80 as surfactants and poly vinyl alcohol (PVA) as a stabilizer by a hot homogenization coupled with ultrasonication method. The formulation were characterized for particle size, polydispersity index, zeta potential (using dynamic light scattering), shape (using atomic force microscopy), drug encapsulation efficiency (using by dialysis and ultracentrifugation methods), and in vitro drug release (using by dialysis).
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    Book chapterItemOpen Access
    Pharmacokinetics of Enrofloxacin Loaded Solid Lipid Nanoparticles following Oral Administration in Emu (Dromaius Novaehollandiae) Birds
    (2014) Senthilkumar, P.; Arivuchelvan, A.; Jagadeeswaran, A.; Subramanian, K.; Senthilkumar, C.; Mekala, P.; TANUVAS
    The study was conducted to formulate the enrofloxacin SLNs and evaluate its pharmacokinetic (PK) behaviour in emus. Enrofloxacin SLNs were prepared by a hot homogenization coupled with ultrasonication method and characterized for further investigation in emus. PK of native enrofloxacin was studied after i.v. and oral bolus administration at 10mg/kg in emus and it was compared with disposition kinetics of enrofloxacin SLNs. Enrofloxacin and its metabolite ciprofloxacin in plasma were estimated using HPLC and PKs were calculated by a noncompartmental analysis.
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    Book chapterItemOpen Access
    MOLECULAR MODES OF ACTION OF PLANT SECONDARY METABOLITES
    (TANUVAS, Chennai, 2017) Senthilkumar, P.; TANUVAS
    Plants have been the basis of many traditional medicine systems throughout the World for thousands of years and still remain as the main new source of structurally important chemical substances that lead to the development of innovative drugs. The use of medicinal plants for the treatment of many diseases is associated with folk medicine from different parts of the World.
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    Book chapterItemOpen Access
    PLANT SECONDARY METABOLITES
    (TANUVAS, Chennai, 2017) Senthilkumar, P.; TANUVAS
    Modern medicines, which are based on synthetic drugs and on antibiotics, have only become available during the last 150 years. Previously, humans had to rely on drugs from nature, mostly from plants, but also from fungi and animals. Medicinal systems around the world, which had been developed thousands of years ago, heavily relied on herbal medicine.