Development and Sustainable Release Evaluation of Enrofloxacin Solid Lipid Nanopartilces
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Date
2014
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Abstract
The study was conducted to formulate the enrofloxacin solid lipid nanoparticles (SLNs) with sustained
release profile and improved pharmacological activity. The enrofloxacin SLNs were prepared using
tripalmitin as lipid carrier, tween 80 and span 80 as surfactants and poly vinyl alcohol (PVA) as a stabilizer
by a hot homogenization coupled with ultrasonication method. The formulation were characterized for
particle size, polydispersity index, zeta potential (using dynamic light scattering), shape (using atomic
force microscopy), drug encapsulation efficiency (using by dialysis and ultracentrifugation methods),
and in vitro drug release (using by dialysis).
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Keywords
Veterinary Science, Veterinary Pharmacology and Toxicology