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ThesisItem Open Access COMPREHENSIVE STUDY ON ASCITES IN DOGS(SRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI - 517 502. (A.P.) INDIA, 2017-12) SREEHARI, M; SURESH KUMAR, R.V(MAJOR); VEENA, P; JAGAPATHI RAMAYYA, PABSTRACT: The present investigation entitled “Comprehensive study on ascites in dogs” was carried out to study comprehensive information on ascites in dogs. 18 dogs of either sex were selected based on inclusion and exclusion criteria divided into three groups of six animals each in one group. Based on clinical and ultrasonographic examination cases were allotted. Group I animals were given medical treatment group II animals received medical treatment and underwent abdominocentesis. Group III animals received medical treatment, abdominocentesis and dialysis procedures. In all the groups various clinical symptoms, changes in physiological, biochemical and haematological parameters were studied. Radiological, ultrasonographic and peritoneal fluid analysis were carried out to differentiate the possible etiological agent for appropriate therapy. Incidence was found to be more in males compared to females. Clinical symptoms like anorexia, weight loss, abdominal distension, lethargy, vomitions were recorded in all the three groups. Medical treatment was carried out using antiemetics, diuretics, antibiotics, protein supplement, hepatoprotective drugs as supportive therapy. Abdominocentesis was adopted in group II in addition to medical treatment whereas abdominocentesis and peritoneal dialysis was adopted in group III. No significant changes were noticed in physiological parameters except fluctuations in respiratory rate and depth. Girth circumference in cm ranged from 20 to 40. Sinus arrhythmias, Tall R-wave and increased R-R interval were few ECG findings recorded in the study. Peritoneal fluid collected from samples showed exudate, moderate exudate and transudate nature. Ground glass appearance was a prominent radiographic feature in all the groups however cardiomegaly, hepatomegaly, splenomegaly were also observed. Ultrasonographic features all the groups included, hyper-echoic floating internal organs in anechoic fluid which were useful in differentiating causative agents and aided in fluid collection. Peritoneal fluid cytological smears examination of samples in the present study revealed more no of neutrophils, mesothelial cells and few erythrocytes. Biochemical and haematological values showed non-significant either increase or decrease in values at different periods of observation. Though satisfactory result was obtained in group I further recurrence was noticed. Abdominocentesis and peritoneal dialysis group II and III revealed good results without much accumulation. One animal in group II and III were reported to be dead. Based on the above study it is concluded that clinical and ultrasonographic examination are essential to differentiate conditions from ascites. Treatment based on etiological agent is better for obtaining good results.ThesisItem Open Access COMPARATIVE EVALUATION OF ROPIVACAINE, ROPIVACAINE – DEXMEDETOMIDINE AND ROPIVACAINE – CLONIDINE COMBINATIONS FOR EPIDURAL ANALGESIA IN CATTLE(SRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI - 517 502. (A.P.) INDIA, 2017-12) CHANDRA SEKHAR, K; VEENA, P(MAJOR); SURESH KUMAR, R.V; JAGAPATHI RAMAYYA, PABSTRACT: Eighteen cattle of either sex presented to the clinic with different surgical conditions like urolithiasis, tumors in perineal region and tail injuries were utilized to study the effects of ropivacaine, ropivacaine – dexmedetomidine and ropivacaine – clonidine combinations for epidural analgesia. The animals were divided into three groups of six animals each. Group I received ropivacaine (0.75%) @ 0.25 mg/kg b.wt at sacrococcygeal space. Group II animals received ropivacaine (0.75%) @ 0.25 mg/kg b.wt and dexmedetomidine @ 5 μg/kg b.wt in the sacrococcygeal space. Group III animals received ropivacaine (0.75%) @ 0.25 mg/kg b.wt and clonidine @ 2 μg/kg b.wt at sacrococcygeal space. The fastest onset of analgesia was produced by ropivacaine –dexmedetomidine combination followed by ropivacaine – clonidine. Profound analgesia was observed in animals following ropivacaine – dexmedetomidine epidural injection. Animals in group II showed rapid abolition and prolonged reappearance of all reflexes followed by group III and group I animals. Rectal temperature showed non significant decrease in all groups during post epidural analgesia. A non significant increase in respiratory rate was observed in cattle following ropivacaine and ropivacaine – clonidine epidural analgesia. Whereas, a non significant fall was noticed in respiratory rate during ropivacaine – dexmedetomidine combination. A non significant increase in heart rate was recorded after epidural administration of ropivacaine in group I animals. Group II and III animals showed a non significant decrease in heart rate throughout the period of study. ECG studies did not reveal any abnormalities except sinus arrhythmia in all animals. In group I and III, non significant increase in Hb and PCV values were observed in the present study. Non significant decrease in Hb and PCV values were recorded in animals subjected to ropivacaine – dexmedetomidine analgesia. A non significant increase in AST, ALT levels was noticed in all groups of animals. The study suggests that dexmedetomidine is a better adjuvant than clonidine in producing epidural analgesia as far as cardio – respiratory and haemato – biochemical parameters are concerned. Therefore, ropivacaine – dexmedetomidine combination can be recommended for safe epidural analgesia in cattleThesisItem Open Access ETIOPATHOGENESIS, DIAGNOSIS AND MANAGEMENT OF EXTRA OCULAR DISEASES IN RUMINANTS(SRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI - 517 502. (A.P.) INDIA, 2017-12) ERESHA, CHAKALI; RAMBABU, K(MAJOR); SURESH KUMAR, R.V; JAGAPATHI RAMAYYA, PABSTRACT: The present investigation was carried out to study etiopathogenesis, diagnosis and management of extra ocular diseases in ruminants. Out of a total of 1286 surgical cases, 7.62 per cent (98) of extra ocular affections over a period of 12 months from October 2016 to September 2017 were reported in ruminants. Methodical physical, clinical and ophthalmological and other investigations were carried out to diagnose extra ocular affections. Different extra ocular affections affecting eyelids, conjunctiva, third eyelid cornea and sclera in ruminants were diagnosed by detailed ophthalmic examination by Schirmer tear test, Fluorescein dye test, Rose Bengal test and IOP methods. In the study highest incidence was recorded in cattle (38.77 %) than other ruminants. Gender wise incidence was higher in females i.e 63.27 per cent compared to males 36.73 per cent. As per anatomical location, the highest incidence of extra ocular affections was recorded in Conjunctiva i.e 43.90 per cent. The highest percentage of prevalence for eyelid (18), conjunctiva (43), third eyelid (11), cornea and scleral (26) affections were recorded in eyelid tumors (27.78 per cent), subconjunctival abscess (30.23 per cent), third eyelid tumors (27.27 percent) and corneal opacity (23.07 percent) respectively. The age group of 1 to 5 years had the highest incidence of 52.04 per cent. Highest incidence was recorded in Left eye (OS) i.e 48.98 per cent than right eye (OD). Subconjunctival abscess, Subconjunctival haematoma, Chemosis, Acute conjunctivitis, third eyelid tumours and ocular coenurus cyst were recorded and suitable medical management and surgical procedure were done. To diagnose extra ocular affections in ruminants detailed physical examination, ophthalmic examination were carried out and the cases were treated effectively by meticulous preparation of the patient, medical management and good surgical techniques or both appropriately for successful recovery.ThesisItem Open Access COMPUTERIZED RADIOGRAPHIC STUDIES OF THORAX IN GERIATRIC DOGS(SRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI - 517 502. (A.P.) INDIA, 2017-12) NAGA GOWTHAMI, G V; Sreenu, Makkena(MAJOR); DEVI PRASAD, V; VENKATA NAIDU, GABSTRACT: The present study computerized radiographic studies of thorax in geriatric dogs was aimed to record the possible radiological signs and classifying them. The thoracic radiographs available in the department were utilized to study the radiological features of the geriatric dogs. The thoracic radiographs with left lateral, right lateral, dorso ventral and ventro dorsal views were studied to identify the lesions. A total of 153 cases with 301 views were categorized as breed and age wise small, medium, large and giant dogs and 7-8, 9-10, 11-13 and 14 years above age groups. The lesions identified on thoracic radiographs were classified as extra thoracic, meditational, tracheal, pleural, diaphragmatic, heart and pulmonary lesions in geriatric dogs. The spondylosis of vertebra and sternum, exostosis of the rib and extra thoracic masses are lesions identified in extra thoracic lesions. Meditational masses, the narrowing or widening of the mediastinum appeared less frequently. The opacity in the cranial mediastinum was the prominent radiological sign. Tracheal calcification was the prominent lesion observed in all the breeds. Pleural effusions, pleural thickening, pleural mass and increased pleural density were the features identified in geriatric dogs. Among the lesions, pleural thickening was the prominent lesion appeared on the radiographs obtained followed by increased pleural density and pleural effusions. The cranial or caudal displacement of the cupula and loss of visualization of the diaphragm were the features observed in geriatric dogs. The details of the cardiac silhouette were observed in all the views. The right atrial enlargement in small and large breeds right ventricular enlargement in medium breeds were the prominent findings where as pericardial effusions were noted in almost all the breeds with a more percentage in medium breeds. The right ventricular enlargement was a prominent radiological feature in all the age groups. The interstitial, vascular, bronchial, alveolar, mixed, patterns, bronchial mineralization, Peribronchial thickening, cavitary lesions, lobar signs, consolidated lung, pneumothorax, generalized increased opacity of lungs were the radiological signs observed in geriatric dogs. The radiological features like bronchial mineralization, Peribronchial thickening, cavitary lesions, lobar signs, consolidated lung, pneumothorax, and generalized increased opacity of lungs were varied in percentages among the lateral views while dorsoventral or ventrodorsal views did not reveal any of the these lesions except bronchial mineralization in few radiographs. The pulmonary patterns observed in the different breeds of the geriatric dogs showed prominent bronchial patterns in all the breeds except in small breeds in which the mixed patterns are with more percentage. The vascular and the alveolar patterns are with less percentage in all the breed dogs. The VHS values were more than the normal range in all breeds with cardiomegaly. The cardio thoracic ratio (CTR) was more than 0.5 in all breeds of dogs except in medium breeds with cardiomegaly. There was a significant difference among the breeds (p≤ 0.005) in Tracheal diameter / Tracheal inlet (TD/TI) ratio in geriatric dogs with cardiomegaly while, no significant difference was noticed in Tracheal Diameter Vs width of proximal third rib (TD/Tr). Small breed dogs were more with metastatic lesions. The common type of metastatic lesion which was noticed in majority of the affected animals was circumscribed multiple nodules.ThesisItem Open Access STUDIES ON SURGICAL MANAGEMENT OF PYOMETRA WITH AND WITHOUT RENAL INVOLVEMENT IN BITCHES(SRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI - 517 502. (A.P.) INDIA, 2017-05) SRINIVASULU REDDY, M; DEVI PRASAD, V(MAJOR); HARI KRISHNA, N.V.V.; NAGAMALLESWARI, YABSTRACT: Canine pyometra is the most frequent infective disease of reproductive tract in intact bitches known to involve kidneys, leading to Systemic Inflammatory Response Syndrome, which can be fatal in bitches. The objective of the work is to elucidate the renal involvement in pyometric bitches subjected for ovariohysterectomy and to identify the suitable biomarkers that can be used to diagnose the disease early. The work was undertaken on twenty four bitches diagnosed with pyometra, which were divided in to two groups. Group I, comprising twelve animals without renal involvement and group II with renal involvement. Higher prevalence was observed in Pomeranian and Spitz breeds, in the age range of 5 to 10 years, renal involvement in animals aged above 10 years which were nulliparous. polydypsia and polyuria were seen in only bitches with renal involvement. The physiological parameters like temperature, pulse and respiration were within normal range. Anaemia and leucocytosis with neutrophilia were the common haematological findings. Total protein concentration was normal however, the albumin concentration was less in both the groups. Serum creatinine values were found elevated in group II while blood urea nitrogen values elevated in both the groups. Gamma glutamyl transferase values elevated significantly, while alkaline phosphatase values increased and were within the reference range in group II. Following ovariohysterectomy, the values restored to normal range in pyometric bitches without renal involvement while, in those with renal involvement, the serum creatinine and blood urea nitrogen values were still higher however, showed a decreasing trend at the end of 30 days. Urinalysis showed decreased Specific gravity in group II, indicating altered concentrating ability of kidneys. Marked proteinuria and increased urine protein and creatinine ratio were also observed. The common bacterial isolates recorded from culturing of uterine discharge were Escherichia coli, Staphylococcus sp, Pseudomonas sp, and streptococcus sp. The sensitivity of radiography in diagnosing pyometra in bitches was 100 per cent owing to the fact that all the animals were referred cases. Enormously distended uterus displaced the intestines cranially and dorsally. Ultrasonography revealed tiny sacculations to large cystic areas with hypoechoic to anechoic contents. Renal lesions could be well detected in bitches with renal involvement. In the latter cases, there were hyper echoic renal medulla and loss of cortico-medullary junction. The histopathological sections made from the uterine tissues obtained after ovariohysterectomy revealed hyperplasia of endometrial glands, extensive cystic degeneration. The intensity of inflammatory cell infiltration was directly related to the degree of distention of the uterus. The sections obtained from chronic cases of closed type of pyometra showed changes like congestion of blood vessels, severe inflammatory cell infiltration in the myometrium. The predominant cell types identified were lymphocytes and plasma cells. The sections obtained from animals with systemic inflammatory response syndrome showed predominant hyperplastic changes in the endometrial layer, which was thrown in to folds along with neutrophilic infiltration in the glandular lumen, severe congestion of the myometrium and margination of neutrophils. The sections obtained from the kidneys of bitches with pyometra showed oedema of the glomerular capsule, glomerular sclerosis, hyaline casts in the tubular lumen, congestion of the renal parenchyma and tubular epithelial degeneration. Moderate tubular degeneration with severe inflammatory cell infiltration was noticed in animals, which died one month after surgery. Surgery was undertaken after stabilization of the patient with fluid therapy, antibiotics, haematinics, and after repetition of blood counts. Ovariohysterectomy was performed with premedication of atropine sulphate, induction by ketamine and diazepam and maintenance by isoflurane. The bitches with renal involvement had transient episodes of apnoea that was managed with sighing. The animals with systemic inflammatory response syndrome (SIRS) were treated with liberal amounts of crystalloids though intravenous alimentation, a diuretic, ciprofloxacin and metronidazole. Two animals did not respond to the treatment, had anuria and succumbed to death. Peritoneal dialysis through abdominal drains fixed at the time of ovariohysterectomy was regularly carried out. In the present study, two animals died of SIRS which did not show any response to the treatment following ovariohysterectomy. This syndrome in the present study was characterized by severe depression, recumbency, oliguria to anuria, vomiting and severe dehydration. Serum creatinine and blood urea nitrogen were found constantly elevated.In the present study, it was concluded that, the parameters like leucocytosis, neutrophilia (>90%) with shift to left and elevated serum creatinine, blood urea nitrogen, alkaline phosphatase, gamma glutamyl transferase, proteinuria, urine protein creatinine ratio and specific gravity of urine could be used to assess the probable renal involvement in bitches with pyometra. It can also be asserted that, higher values of these parameters would indicate the increased probability of pyometric bitches ending up with SIRS.ThesisItem Open Access MINIMALLY INVASIVE PLATE OSTEOSYNTHESIS (MIPO) FOR RADIUS AND TIBIA FRACTURE STABILISATION USING LIMITED CONTACT DYNAMIC COMPRESSION PLATE IN DOGS(SRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI - 517 502. (A.P.) INDIA, 2017-03) SEQUEIRA STACY DANIELLAABSTRACT : The present study was conducted on six clinical cases with diaphyseal fractures of radius and tibia presented to the Dept. of Veterinary Surgery and Radiology, NTR College of Veterinary Science, Gannavaram. All the animals were subjected to thorough clinical and orthopaedic examination. Mediolateral and craniocaudal radiographs of the fractured bone and the contralateral limb taken were useful in confirmatory diagnosis, classification of fracture, selection of implants and pre-contouring of plates. The fractures were temporarily stabilised with MRJ till the day of surgery. All the fractures were stabilized with LC-DCP using self-tapping cortical screws. A craniomedial approach was used for radius fractures and medial approach was used for tibia fractures. Following fracture stabilization with LC-DCP post-operative clinical, radiographic and serum biochemical evaluation was carried out on the immediate post-operative, 15th, 30th and 60th POD s. Out of the 6 cases, Case no. 6 started weight bearing on the 2nd POD, Case no. 3 started weight bearing on the 3rd POD, Case no. 1 on the 5th POD and Case no’s. 4 and 5 by the 10th POD. The dogs showed completely normal gait by the 30th POD. Radiographic union was observed by the 30th POD in two cases and by 60th POD in the remaining four cases. Primary healing was observed in five cases whereas one healed by secondary healing. No complications were noticed in any case except malposition of plate in one case. Limb usage was evaluated on the 60th POD and graded as excellent in five cases and fair in one case. Serum values of calcium, phosphorus and alkaline phosphatase were in the normal range during the study period and showed nonsignificant difference between various intervals.ThesisItem Open Access COMPARATIVE EVALUATION OF POSITIVE PROFILE END THREADED INTRAMEDULLARY PINNING AND CROSS PINNING TECHNIQUES FOR DISTAL FEMORAL FRACTURES IN DOGS.(SRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI - 517 502. (A.P.) INDIA, 2017-01) SUBHASHCHANDRABOSE, G; RAGHUNATH, M(MAJOR); HARIKRISHNA, N.V.V.; LAKSHMI RANI, NABSTRACT: The present study was conducted on thirteen clinical cases with distal femoral fractures to study the use of two internal fixation techniques namely Positive Profile, End Threaded, Selftapping, Intramedullary pinning and Cross pinning and to compare the postoperative fracture healing implant related complications pertaining to these techniques. History, signalment, clinical evaluation, haematological, biochemical and radiographic evaluation and clinical outcome were recorded in all the cases. The animals were randomly divided into 2 groups. In Group I, the fractures were stabilized by Positive, Profile, End Threaded, Self-tapping, intramedullary pinning and in Group II, the fractures were stabilized by Cross pinning using K-wires. In Group I, the 60th postoperative day radiographs of dogs 1, 3, 4, 5, 6, 7 revealed complete fracture healing with no evidence of fracture line along with cortical and medullary continuity and signs of remodeling. In Group II, the 60th postoperative day radiographs of all the dogs revealed complete healing of fracture with cortical and medullary continuity with no evidence of fracture line. In Group I, complete weight bearing on the operated limb while walking and standing was seen by 5th postoperative day in majority of dogs. In Group II, complete weight bearing on the operated limb while walking and standing was seen by 15th postoperative day in majority of the dogs. In Group I, there was only one complication of osteomyelitis (dog 2), where as in Group II, two dogs (4 and 6) showed implant related complications like pin migration and dislodgement of pins and in dog 3, medial luxation of patella on 15th postoperative day was noticed without adverse effect on clinical outcome. Based on weight bearing patterns and radiographic evaluation of fracture healing the clinical outcome was excellent in six cases and poor in one case of group I and in group II, the clinical outcome was excellent in all cases. Cross pinning technique had more implant related complications than PPETST intramedullary pinning with no adverse effects on fracture healing.ThesisItem Open Access STUDIES ON SPARING EFFECT OF BUTORPHANOL AND KETAMINE FOR XYLAZINE / DEXMEDETOMIDINE INDUCTION ON ISOFLURANE ANAESTHESIA FOR ELECTIVE OVARIOHYSTERECTOMY IN DOGS(SRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI - 517 502. (A.P.) INDIA, 2017-01) VAMSY KRISHNA YADAV, D; BHARATHI, S(MAJOR); DEVI PRASAD, V; VENKATA NAIDU, GABSTRACT: The present study was conducted to compare the sparing effect of Dexmedetomidine, Butorphanol, Ketamine combination (group I) and Xylazine, Butorphanol, Ketamine combination (group II) induction on isoflurane for elective ovario hysterectomy in twelve bitches which were divided into two groups of six animals each. Both groups received Atropine sulphate @ 0.02 mg/kg b.wt. sc. 20 minutes prior to induction of anaesthesia. In group I all bitches were given same dose rates of induction combination of drugs i.e., Dexmedetomidine @ 5 μgm/kg b.wt, Butorphanol @ 0.1 mg/kg b.wt and Ketamine @ 1mg/kg b.wt. and in group II all animals received Xylazine @ 0.2 mg/kg b.wt, Butorphanol @ 0.1 mg/kg b.wt and Ketamine @ 1mg/kg b.wt mixed in a single syringe and administered intravenously followed by maintenance with Isoflurane in oxygen. The dose rates of drugs required for quick induction of general anaesthesia in group I were found to be Dexmedetomidine @ of 6 μgm/kg b.wt, Butorphanol @ 0.1 mg/kg b.wt and Ketamine @ 4mg/kg b.wt. and in group II, it was Xylazine @ 0.6 mg/kg b.wt, Butorphanol @ 0.1 mg/kg b.wt and Ketamine @ 4mg/kg b.wt. Good quality of induction was seen in group II compared to group I. The changes in body temperature, cardiovascular, pulmonary, haemato-biochemical parameters were studied. Hb, PCV, TEC and TLC decreased from pre-medication to recovery in both the groups. The cardiovascular parameters increased up to maintenance and respiratory parameters showed reduction during induction and increased during maintenance and decreased during recovery. Serum biochemical parameters showed non-significant changes in both groups. The time for extubation and time for total recovery from anaesthesia was lower in group II. The mean vaporizer setting for maintenance and total quantity of isoflurane consumed was lower in group II compared to group I. It is concluded that Butorphanol and Ketamine combination with Xylazine had more sparing effect on Isoflurane when compared to Butorphanol and Ketamine with Dexmedetomidine on isoflurane in dogs that underwent elective ovariohysterectomyThesisItem Open Access EVALUATION OF NEOMYCIN LOADED COLLAGEN SCAFFOLDS FOR CUTANEOUS WOUND HEALING IN RABBITS(SRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI – 517 502. (A.P) INDIA, 2017-03) AMULYA, CHENGALASETTY; SURESH KUMAR, R.V(Major); HARI KRISHNA, N.V.V; VENKATA NAIDU, GABSTRACT: In the present study the neomycin loaded collagen scaffolds were prepared, charecterized, optimised to evaluate its invivo efficacy compared with neomycin sulphate ointment and control. A study was conducted on eighteen rabbits divided into three groups of six animals comprising group-I as control group. The commercially available neomycin ointment was used in the group-II. The neomycin loaded collagen scaffolds were procured after standardization and evaluation by different physical methods in group-III. Cutaneous wounds were created at the loin region of all the animals and the wounds were left unsutured in control group, neomycin ointment was applied in group-II and same sized neomycin loaded collagen scaffolds were applied on group-III animals. These were evaluated by clinical, physiological, gross, haematological, biochemical and histological studies. Group-III animals showed early healing compared to group-I and group-II. These neomycin loaded collagen scaffolds did not alter the physiological parameters. The total erythrocyte count, haemoglobin and PCV values in group-I and group-III showed either significant or nonsignificant fluctuations throughout the observation period but were within normal range, whereas in group-II total erythrocyte count and PCV decreased significantly on day-7 but by day-14 they returned to normal range. The total leucocyte count values in group-I and group-II, differed nonsignificantly (P> 0.01), whereas in group-III, a significant increase by day-7 followed by significant decrease reaching normal range by day 14 was observed. Differential leucocyte count, neutrophil count, and lymphocyte count showed significant difference (P<0.001) among the groups and nonsignificant difference within groups. The eosinophil, basophil and monocyte counts in all the groups though significant changes, fluctuated within the normal range.Hydroxyproline showed significant (P<0.001) changes among the groups and also within the groups. In group-I and group-II the values increased significantly from the base value till day-14, whereas in group-III values increased significantly (P<0.01) on day-7 followed by a significant decrease on day-14. Hexosamine values showed significant increase from the base values on day-7 in all the groups followed by significant decrease on day-14 in group-I and group-II, whereas in group-III, the value increased significantly on day-14. Iron values showed significant changes among the groups and also within the group but higher value on day-7 which were decreased on by day-14. Copper values showed non significant fluctuations till day-7 in all groups followed by significant increase on day-14. Zinc values increased significantly in group- II, whereas in group-I and III the values fluctuated non significantly. None of the animals showed a positive reaction for Creactive protein at different periods of observations in all the groups. Early fibroplasia, neovascularization and epithelialisation were noticed in group III, compared to other two groups.Based on the observations in the present study it was concluded that neomycin loaded collagen scaffold could be used safely for cutaneous wound healing without any adverse effects.