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Subject: Veterinary Pharmacology and Toxicology × Author: SRIVIDYA, GULLAPUDI × End date: 2007 × Start date: 2007 ×
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    ThesisItemOpen Access
    STUDIES ON ANTIHEPATOTOXIC POTENTIAL OF ACORUS CALAMUSRHIZOME EXTRACT IN RATS
    (SRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI - 517 502. (A.P.) INDIA, 2007-01) SRIVIDYA, GULLAPUDI; VENKATESWARLU, U(MAJOR); ADILAXMAMMA, K; SRILATHA, Ch
    ABSTRACT: Hepatotoxicity is one of the major problem encountered in animals as well as in human beings, as the liver is the major target for metabolism of various xenobiotics. Herbal drugs are gaining importance now a clays, as reliable drugs in modem medicine are lacking. Acorus calamw is one of the important medicinal plant in traditional system of Indian medicine. The rhizomes of Acorus calamus possess various medicinal properties and antioxidant activity. The aqueous and alcoholic extracts of Acorus calumus were tssted for their antihepatotoxic potential in rats. Forty eight male wistar albino rats were divided into six groups having eight in each. Group I served ap control (WC) and group Il served as paracetam01 control. Group I1 to VI received paracetam01 @ 2 g w' b.wt. p.o on day one. Forty eight hours post administration of prmebnml, group II dved 0.5 per cent CMC for 10 9s. Gmup III and N received alcoholic d aqueous atracts @ 600 mg kg' b.wt. p.o for ten days, pup V and VI received silymarin and Vit.E @ 25 mg kg-' b.wt. and 30 mg kg" b.wt. p.o for ten days, respectively. Twenty four hours after last day of treatment the rats were sacrificed. The antihepatotoxic potential of Acorus calamus was compared with silymarin and Vit.E. Results obtained from the study revealed that paracetamol administration resulted in significant (P<0.01) reduction in GSH, GPx, GSH-R' and catalase in erythrocytes. It also resulted in significant (P<0.01) elevation of AST, ALT, ALP concentrations and hypoproteinemia in senun and elevation of TBARS in hepatic tissue. Treatment with Acorn calamus, silymarin and Vit.E prevented the above mentioned paracetamol induced changes. The biochemical alterations were correlated with the histopathological findings of liver sections