STUDIES ON ANTIHEPATOTOXIC POTENTIAL OF ACORUS CALAMUSRHIZOME EXTRACT IN RATS
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Date
2007-01
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SRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI - 517 502. (A.P.) INDIA
Abstract
ABSTRACT:
Hepatotoxicity is one of the major problem encountered in animals as
well as in human beings, as the liver is the major target for metabolism of
various xenobiotics. Herbal drugs are gaining importance now a clays, as
reliable drugs in modem medicine are lacking. Acorus calamw is one of the
important medicinal plant in traditional system of Indian medicine. The
rhizomes of Acorus calamus possess various medicinal properties and
antioxidant activity. The aqueous and alcoholic extracts of Acorus calumus
were tssted for their antihepatotoxic potential in rats. Forty eight male
wistar albino rats were divided into six groups having eight in each. Group I
served ap control (WC) and group Il served as paracetam01 control. Group
I1 to VI received paracetam01 @ 2 g w' b.wt. p.o on day one. Forty eight
hours post administration of prmebnml, group II dved 0.5 per cent
CMC for 10 9s. Gmup III and N received alcoholic d aqueous atracts
@ 600 mg kg' b.wt. p.o for ten days, pup V and VI received silymarin
and Vit.E @ 25 mg kg-' b.wt. and 30 mg kg" b.wt. p.o for ten days,
respectively. Twenty four hours after last day of treatment the rats were
sacrificed. The antihepatotoxic potential of Acorus calamus was compared
with silymarin and Vit.E. Results obtained from the study revealed that
paracetamol administration resulted in significant (P<0.01) reduction in
GSH, GPx, GSH-R' and catalase in erythrocytes. It also resulted in
significant (P<0.01) elevation of AST, ALT, ALP concentrations and
hypoproteinemia in senun and elevation of TBARS in hepatic tissue.
Treatment with Acorn calamus, silymarin and Vit.E prevented the
above mentioned paracetamol induced changes. The biochemical alterations
were correlated with the histopathological findings of liver sections
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