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Subject: Veterinary Pharmacology and Toxicology × Author: MURALI KRISHNA, M × End date: 2016 × Start date: 2010 ×
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    ThesisItemOpen Access
    IN VITRO STUDIES ON MODULATION OF CONTRACTILE AND RELAXANT RESPONSES OF SHEEP TRACHEAL SMOOTH MUSCLE BY MORIN
    (SRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI - 517 502. (A.P.) INDIA, 2016-07) MURALI KRISHNA, M; BHARAVI, K(MAJOR); Ravi Kumar, P; Satheesh, K
    ABSTRACT: Morin (3,5,7,2,4 - pentahydroxyflavone), belongs to the flavonoid group of polyphenolic compounds found in wood of old fustic, in osage orange, white mulberry, fig, almond and sweet chestnut, and many other herbs and fruits used as herbal medicines. Morin has been the subject of a number of experimental studies dealing with its pharmacological activities, such as antioxidant properties, inhibition of lipid peroxidation, anti cancer activity, anti-inflammatory activity, cardiovascular protection and also a prooxidant action. Despite the enormous interest in flavonoids as potential therapeutic agents, their biological activity mechanisms are poorly understood and largely unknown, but different types of possible biochemical events are involved. In view of this, the present study is designed to know the modulatory effect of morin hydrate on contractile and relaxant responses of various pharmacological agents like acetylcholine and atropine, histamine and cetirizine, KCl and nifedipine in sheep tracheal smooth muscle in vitro. Mean EC50 values for contractile response of acetylcholine obtained in the absence of morin hydrate were 3.38×10-7M (5×10-9M to 15×10-6M) and in presence of morin hydrate it was increased to 6.02×10-7M (5×10-9M to 15×10-5M) with a significant right shift. Mean EC50 values for contractile response of histamine obtained in the absence of morin hydrate were 1.12×10-6M (5×10-9M to 30×10-5M) and in presence of morin hydrate it was increased to 2.63×10-6M (5×10-9M to 30×10-5M) with a significant right shift. Mean IC50 values for relaxant response of atropine, cetirizine and nifedipine in comparison with morin hydrate in sheep tracheal smooth muscle were 2.23×10-8M (5×10- 9M to 5×10-6M), 3.46×10-8M (5×10-9M to 15×10-6M), 6.30×10-6M (5×10-9M to 30×10- 5M) and 6.30×10-7M (5×10-9M to 15×10-6M), 1.58×10-6M (5×10-9M to 5×10-5M), 2.04×10-5M (5×10-9M to 15×10-4M) respectively. The study revealed that morin hydrate has relaxant effect on the sheep trachealis smooth muscle in vitro.