Thumbnail Image

Thesis

Browse

20221
Reset filters
Subject: Veterinary Gynaecology and Obstetrics × Author: LEELA MANI, B × End date: 2022 × Start date: 2022 ×
Reset filters

Search Results

Now showing 1 - 1 of 1
  • Thumbnail Image
    ThesisItemOpen Access
    THERAPEUTIC EFFICACY OF IMMUNOMODULATORS IN SUBCLINICAL ENDOMETRITIS OF CROSSBRED COWS
    (SRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI - 517 502. (A.P.) INDIA, 2022-08) LEELA MANI, B; VENKATA NAIDU, G(MAJOR); SRINIVAS, MANDA; SREENU, MAKKENA
    The present investigation was conducted to assess the clinical recovery from subclinical endometritis following the treatment with double prostaglandin injections (Group 1; n=10) and intrauterine infusion of E. coli LPS (Group 2; n=10) in comparison with phosphate buffer saline (Group 3; n=10) in crossbred cows by pH and uterine discharge cytology. The characterization of repeat breeding in crossbred cows (n=105) based on per-rectal palpation of the reproductive tract, revealed that 13.33% had cystic ovarian degeneration, 68.57% had endometritis, 5.72% had mucometra/ hydrometra, 11.43% had kinked or fibrosed cervix and 0.95% had uterine adhesions. Of which, endometritis was the most common cause with an occurrence of 68.57 (72/105) per cent. Occurrence of subclinical endometritis based on per rectal examination, appearance of cervico-vaginal mucus (score), pH and uterine discharge cytology was 63.89, 63.89, 58.33 and 51.39 per cent, respectively. While, occurrence of clinical endometritis was 36.11, 36.11, 41.67 and 48.61 per cent, respectively. Subclinical endometritis could be diagnosed preliminarily based on pH and appearance of cervico-vaginal mucus. Uterine discharge cytology by aspiration technique and staining with Field’s stain could be easily performed at field level. Biochemical cues (metabolites, enzymes and minerals) revealed that variations in serum at post-treatment estrus as compared to pretreatment estrus values indicated the clearing of uterine infection after therapy. In the present study, intrauterine infusion of E.coli LPS (100 μg) yielded promising recovery (90.00%) and conception rates (88.88%) in the treatment of subclinical endometritis affected crossbred cows as compared to double prostaglandin injections (80.00% Vs 62.50%)and intrauterine infusion of phosphate buffer saline (30.00% Vs 33.33%). In conclusion, therapy with E.coli LPS could be effectively used as an alternative to traditional intrauterine antibiotic therapy or antimicrobial agents with better efficacy to cure the subclinical endometritis by promoting uterine defense mechanism.