THERAPEUTIC EFFICACY OF IMMUNOMODULATORS IN SUBCLINICAL ENDOMETRITIS OF CROSSBRED COWS
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Date
2022-08
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SRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI - 517 502. (A.P.) INDIA
Abstract
The present investigation was conducted to assess the clinical
recovery from subclinical endometritis following the treatment with
double prostaglandin injections (Group 1; n=10) and intrauterine
infusion of E. coli LPS (Group 2; n=10) in comparison with phosphate
buffer saline (Group 3; n=10) in crossbred cows by pH and uterine
discharge cytology.
The characterization of repeat breeding in crossbred cows
(n=105) based on per-rectal palpation of the reproductive tract,
revealed that 13.33% had cystic ovarian degeneration, 68.57% had
endometritis, 5.72% had mucometra/ hydrometra, 11.43% had kinked
or fibrosed cervix and 0.95% had uterine adhesions. Of which,
endometritis was the most common cause with an occurrence of 68.57
(72/105) per cent.
Occurrence of subclinical endometritis based on per rectal
examination, appearance of cervico-vaginal mucus (score), pH and
uterine discharge cytology was 63.89, 63.89, 58.33 and 51.39 per cent,
respectively. While, occurrence of clinical endometritis was 36.11,
36.11, 41.67 and 48.61 per cent, respectively.
Subclinical endometritis could be diagnosed preliminarily based
on pH and appearance of cervico-vaginal mucus. Uterine discharge
cytology by aspiration technique and staining with Field’s stain could
be easily performed at field level.
Biochemical cues (metabolites, enzymes and minerals) revealed
that variations in serum at post-treatment estrus as compared to pretreatment
estrus values indicated the clearing of uterine infection after
therapy. In the present study, intrauterine infusion of E.coli LPS (100 μg)
yielded promising recovery (90.00%) and conception rates (88.88%) in
the treatment of subclinical endometritis affected crossbred cows as
compared to double prostaglandin injections (80.00% Vs 62.50%)and
intrauterine infusion of phosphate buffer saline (30.00% Vs 33.33%).
In conclusion, therapy with E.coli LPS could be effectively used as an
alternative to traditional intrauterine antibiotic therapy or
antimicrobial agents with better efficacy to cure the subclinical
endometritis by promoting uterine defense mechanism.
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