EFFICACY OF IMMUNOMODULATORS IN THE TREATMENT OF SUBCLINICAL ENDOMETRITIS IN THE GRADED MURRAH BUFFALOES (Bubalus bubalis)
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Date
2021-05
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SRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI - 517 502. (A.P.) INDIA
Abstract
The present investigation was conducted to assess the clinical recovery from subclinical endometritis following the treatment with intrauterine infusion of E. coli LPS (Group 1; n=8) and double cloprostenol injections (Group 2; n=8) in comparison with apparently healthy control buffaloes (Group 3; n=8) by pH, white side test, uterine discharge cytology and bacterial load.
The characterization of repeat breeding in Graded Murrah buffaloes based on the clinical condition of the reproductive tract, revealed that buffaloes had cystic ovarian degeneration (2.35%), cystic endometrium (1.18%), endometritis (74.11%), mucometra (1.18%), uterine/ovarian tumours (1.18%), ovario-bursal adhesions (1.18%), had kinked or fibrosed cervix (17.64%) and uterine adhesions (1.18%) among 85 repeat breeder buffaloes screened. Amongst the buffaloes with history of failure of conception, the most predominant cause was endometritis with an occurrence of 74.11 per cent.
Occurrence of subclinical endometritis based on per rectal per- examination, appearance of cervico-vaginal mucus (score), pH, white side test, optical density and uterine discharge cytology was 85.71, 61.90, 82.54, 82.54, 85.71 and 69.84 per cent, respectively. While, occurrence of clinical endometritis was 14.29, 38.10, 17.46, 17.46, 14.29 and 30.16 per cent, respectively. Bacterial load was significantly (P0.05) alterations in Hb (gm/dl), PCV (%), serum total protein (gm/dl), aspartate aminotransferase (IU/L) and alanine aminotransferase (IU/L) values in both treatments and healthy control groups at before treatment and at subsequent estrus after treatment. Whereas, the difference was significant with regards to neutrophil and lymphocyte counts (%) in Group 1 and Group 2 buffaloes.
In the present study, higher percentage of recovery rate (87.50% Vs 75.00%) and conception rate (85.71% Vs 66.67%) were recorded with E. coli LPS (Group 1) compared to double cloprostenol treatment (Group 2). In conclusion, therapy with E.coli LPS could be used effectively as an alternative to the traditional antibiotics with better efficacy to resolve the subclinical uterine infection mediated through uterine defense mechanism.
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