STUDIES ON FENTANYL PREMEDICATION ON CERTAIN ANAESTHETIC COMBINATIONS IN CANINES
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Date
2006-02
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SRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI - 517 502. (A.P.) INDIA
Abstract
ABSTRACT:
The present study was conducted on twelve animals to study the
effect of fentanyl premedication on different anaesthetic combinations in
bitches which were divided into two groups of six animals in each group.
Fentanyl was administered in both the groups @ 2 mdkg body weight
intravenously. Later xylazine and thiopentone sodium (2.5%) were given
intravenously at the dose rate of 1 mg and 10 mg/kg body weight
respectively in group I. In group I1 propofol and thiopentone sodium
(2.5%) were administered intravenously at the dose rate of 5 mg and 10
mgkg body weight, respectively. Induction was smooth and excellent
without any struggling in both the groups. Good muscle relaxation and
early abolishing of all reflexes were noticed in group I1 animals compared
to group I. The recovery was smooth and uneventful without any post
anaesthetic complications in both the groups, however it was early in
group 11.Rectal temperature showed nonsignificant fall upto 60 min in both
the groups and were within normal range. Respiratory rates showed a
nonsignificant fall following drug administration in both the groups
through out the observation period. Pulse rates showed a significant fall
in both the groups throughout the observation period, upto 2 hrs in group
I and upto 4 hrs in group 11. SPOz values were within normal
physiological range during the entire period of observation.
The haematological parameters like TEC, TLC and Hb values did
not show any significant changes, however they fluctuated within the
normal range. The packed cell volume values in group I showed a
significant fall upto 2 hrs after drug administration whereas group I1
animals recorded a significant rise at 60 minutes observation period.
Changes in ALT, AST, glucose and protein were not statistically
significant and fluctuated within the normal physiological range in both
the groups.
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