Malignant histiocytosis in a dog: A case report

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dc.contributor.authorLalrinkima
dc.contributor.authorThangapandiyan, M
dc.contributor.authorHemalatha, S
dc.contributor.authorSudhakar Rao, GV
dc.contributor.authorTANUVAS
dc.date.accessioned2020-01-02T06:22:28Z
dc.date.available2020-01-02T06:22:28Z
dc.date.issued2019
dc.descriptionTNV_JEZS_2019_7(6)951-953en_US
dc.description.abstractA 3 year old male German Shepherd was presented with a history of swelling on the submandibular region and was brought to Madras Veterinary College, Chennai-600 007 for postmortem examination. Necropsy examination revealed a 10-15 cm white lobulated mass on the right side of subcutis of the submandibular region. Internal examination revealed nodules on cortex of both the kidneys. Severe ulcerative lesions was seen in the stomach and duodenum. Cytologically, discrete round cells pleomorphic, with abundant cytoplasm and ovoid and indented nuclei. Histopathological examination revealed diffuse infiltration of large round to pleomorphic cells with abundant eosinophilic cytoplasm with ovoid to bean shaped nuclei with distinct cell margins. The cells were arranged as loose sheets with minimal fibrous stroma. Nuclei were hyperchromatic with prominent multiple nucleoli. Scanty mitoses was observed. For differential diagnosis of round cell tumors mast cells were ruled out by toludine blue staining which was found to be negative. Immunohistochemistry for mast cell tumor was carried out for Ckit and was found to be negative. Specific expression of immunohistochemical markers for histiocytic cell type CD 18 showed diffuse intense cytoplasmic positivity for the markers. Both dermal and metastatic areas in the kidney expressed these specific histiocytic markers.en_US
dc.identifier.urihttp://krishikosh.egranth.ac.in/handle/1/5810139190
dc.keywordsDog, malignant histiocytosis, pathologyen_US
dc.language.isoenen_US
dc.pages951-953en_US
dc.relation.ispartofseries;6
dc.subjectVeterinary Scienceen_US
dc.titleMalignant histiocytosis in a dog: A case reporten_US
dc.title.alternativeJournal of Entomology and Zoology Studiesen_US
dc.typeArticleen_US
dc.volume7en_US
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