Haemato-biochemical changes during nalbuphine xylazineacepromazine- ketamine anaesthesia in horses
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Date
2015-12
Journal Title
Journal ISSN
Volume Title
Publisher
Indian Society for Veterinary Surgery
Abstract
The objective of the study was to evaluate cardiopulmonary
and haematobiochemical changes and stress response
associated with administration of nalbuphine HCl during
ketamine anaesthesia in horses premedicated with xylazine or
xylazine-acepromazine. Eighteen clinical cases of horses
brought for diagnostic and surgical procedures requiring
general anaesthesia were randomly divided into three groups,
I, II and III, each consisting of six animals. All the horses were
premedicated with glycopyrrolate 0.02 mg/kg b.wt, i.v. Horses
in group I and group II were administered xylazine HCl 1.10
mg/kg b.wt, i.v. In group III, 0.50 mg/kg b.wt xylazine HCl
was administered i.v., followed by acepromazine 0.02 mg/kg
b.wt, i.v. Before induction of anaesthesia, nalbuphine HCl was
administered in group II and group III animals @ 0.75 mg/kg
b.wt, i.v. Ketamine HCl was administered i.v. to induce
anaesthesia @ 2.20 mg/kg b.wt and maintained with 0.50 mg/
kg b.wt in required cases for duration of 15±1.04 min. The
heart rate increased during intraoperative period reached
baseline value 6 hr after surgery. The respiratory rate and
mean saturated partial pressure of oxygen decreased
significantly during intraoperative period. Haemoglobin, PCV,
TEC and TLC decreased significantly; the neutrophil and
monocyte counts increased and the lymphocyte count decreased
significantly during intraoperative and postoperative period
in all the groups. The blood glucose, creatinine, plasma cortisol
and plasma catalase activity significantly increased during
intraoperative period and postoperative period. The total
protein values significantly decreased during the intraoperative
period in all the groups. To conclude, administration of
nalbuphine HCl did not produce any marked changes in
cardiopulmonary, haematobiochemical parameters and
produced less stress response.
Description
TNV_IJVS_2015_36(2)82-87
Keywords
Veterinary Science