Clinico-therapeutic evaluation of polyherbal formulations in diarrhoeic calves
Loading...
Date
2004-04
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
G.B. Pant University of Agriculture and Technology, Pantnagar - 263145 (Uttarakhand)
Abstract
The present investigation was undertaken to evaluate clinico-haematobiochemical parameters, total fluid deficit and therapeutic efficacy of five treatments in natural cases of diarrhoea in calves. Six calves with no sign of diarrhoea were also included as healthy control. Clinical examination of diarrhoeic calves revealed semisolid to watery faeces and loss of appetite besides dry mucous membrane, sunken enophthalmos, dull to strenal recumbency, loss of skin elasticity and cool extremities in varying number of calves. Diarrhoeic calves had significantly higher haemoglobin concentration, packed cell volume and total erythrocyte count and lower total leucocyte count, mean corpuscular haemoglobin and mean corpuscular haemoglobin concentration. Differential leucocyte count revealed neutrophilia and lymphopenia. Biochemical findings of affected calves revealed significant increase in blood urea nitrogen, serum total proteins, albumin, globulins, chloride and potassium and decrease in albumin globulins ratio and serum sodium. Total fluid deficit (TFD) in diarrhoeic calves estimated on the basis of clinical approach and based on laboratory approach indicated a significant difference in TFD between these two approaches. Alcoholic extracts of Terminalia chebula and Cuminum cyminum and aqueous extracts of Eugenia jambolana, Cassia absus, Terminalia chebula and Cuminum cyminum in concentration of 500 mg/ml possessed in-vitro anti-E. coli activity. Polyherbal formulation-1 containing Eugenia jambolana, Aegle marmelos, Terminalia chebula and Zingiber officinale and intrim bolus were found to have equally high therapeutic efficacy for treatment of diarrhoea in cases with 100% recoveries and significant improvement in clinico-haematobiochemical profiles. The recovery in diarrhoeic calves treated with polyherbal formulation-2 containing Cuminum cyminum, Kalanchoe pinnata, Helicteres isora and Cassia absus was 83.33% and 50% at the dose level of 15 gm and 7.5 gm respectively. Polyherbal formulation-1 at the dose level of 15 gm and 7.5 gm b.i.d. for 3-5 days was found to be an effective and cheap therapeutic alternative for the treatment of diarrhoea in calves of below 30 days of age.
Description
Keywords
null