Synthesis of indole derivatives and their antimicrobial activity

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dc.contributor.advisorUtreja, Divya
dc.contributor.authorJain, Palak
dc.date.accessioned2019-11-12T04:25:54Z
dc.date.available2019-11-12T04:25:54Z
dc.date.issued2019
dc.description.abstractA novel series of eleven C-3 and N-1 substituted oxoacetamide indole derivatives were synthesized by reacting with various aromatic amines and alkyl halides. These compounds were characterized by using 1HNMR, 1HNMR-D2O, 13CNMR and IR spectroscopy. In vitro, antimicrobial studies of resultant compounds were carried out by using disc plate method against two bacterial strains Pseudomonas aeruginosa and Pseudomonas oryzihabitans. All the tested compounds showed vital efficiency as antimicrobial agents against both the bacterial strains. The results revealed that synthesized indole derivative 2-(1-(3-bromopropyl)-1H-indol-3-yl)-N-(2-nitrophenyl)-2-oxoacetamide displayed best antimicrobial activity as compared to all other synthesized compounds.en_US
dc.identifier.urihttp://krishikosh.egranth.ac.in/handle/1/5810135069
dc.keywordsIndole, N-alkylation, Antimicrobial activity, Pseudomonas aeruginosa, Pseudomonas oryizihabitans, Zone of inhibitionen_US
dc.language.isoenen_US
dc.pages63en_US
dc.publisherPunjab Agricultural University, Ludhianaen_US
dc.research.problemSynthesis of indole derivatives and their antimicrobial activityen_US
dc.subChemistryen_US
dc.subjectnullen_US
dc.themeSynthesis of indole derivatives and their antimicrobial activityen_US
dc.these.typeM.Scen_US
dc.titleSynthesis of indole derivatives and their antimicrobial activityen_US
dc.typeThesisen_US
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