Synthesis of indole derivatives and their antimicrobial activity
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Date
2019
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Punjab Agricultural University, Ludhiana
Abstract
A novel series of eleven C-3 and N-1 substituted oxoacetamide indole derivatives were synthesized by reacting with various aromatic amines and alkyl halides. These compounds were characterized by using 1HNMR, 1HNMR-D2O, 13CNMR and IR spectroscopy. In vitro, antimicrobial studies of resultant compounds were carried out by using disc plate method against two bacterial strains Pseudomonas aeruginosa and Pseudomonas oryzihabitans. All the tested compounds showed vital efficiency as antimicrobial agents against both the bacterial strains. The results revealed that synthesized indole derivative 2-(1-(3-bromopropyl)-1H-indol-3-yl)-N-(2-nitrophenyl)-2-oxoacetamide displayed best antimicrobial activity as compared to all other synthesized compounds.
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