Role of co-administration of antioxidants in prevention of oxidative injury following sub-chronic exposure to arsenic in rats

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dc.contributor.authorPatra, R.C
dc.contributor.authorSwarup, D
dc.contributor.authorNandi, D
dc.contributor.authorRanjan, Rakesh
dc.date.accessioned2018-03-07T10:36:40Z
dc.date.available2018-03-07T10:36:40Z
dc.date.issued2018-03-07
dc.description.abstractIn this experiment thirty rats were exposed to 0 (Gr. I, healthy controls) or 10 ppm arsenic (sodium arsenite) through drinking water ad lib for eight weeks after dividing them into five groups of six rats each. Rats in Gr. III, IV and V were administered a daily oral dose of cysteine, methionine or ascorbic acid 25 mg/kg body mass respectively, while those in Gr. II served as the treated control. At the end of the experimental period oxidative stress indices viz. lipid peroxides level (LPO), superoxide dismutase (SOD) and catalase (CAT) activities were estimated in blood, liver and kidneys from sacrificed rats. Arsenic exposure resulted in a significant (P<0.05) rise in LPO levels and activities of SOD and CAT in erythrocytes, liver and kidneys. All the different treatments reduced lipid peroxides levels and restored activities of antioxidant enzymes to variable extents in various tissues. However, arsenic exposure did not show any significant (P>0.05) effects on the body mass of rats of different groups over time. It is concluded from the present study that prophylactic co-administration of cysteine, methionine and ascorbic acid could provide tissue specific protection from oxidative injury during sub-chronic exposure to arsenic.en_US
dc.identifier.citationVeterinarski Arhiv 78 (2), 113-121, 2008en_US
dc.identifier.urihttp://krishikosh.egranth.ac.in/handle/1/5810041588
dc.keywordsantioxidants, arsenic, ascorbic acid, cysteine, methionine, raten_US
dc.language.isoenen_US
dc.pages10en_US
dc.subjectnullen_US
dc.titleRole of co-administration of antioxidants in prevention of oxidative injury following sub-chronic exposure to arsenic in ratsen_US
dc.typeArticleen_US
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