Role of co-administration of antioxidants in prevention of oxidative injury following sub-chronic exposure to arsenic in rats
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Date
2018-03-07
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Abstract
In this experiment thirty rats were exposed to 0 (Gr. I, healthy controls) or 10 ppm arsenic (sodium arsenite)
through drinking water ad lib for eight weeks after dividing them into five groups of six rats each. Rats in Gr.
III, IV and V were administered a daily oral dose of cysteine, methionine or ascorbic acid 25 mg/kg body mass
respectively, while those in Gr. II served as the treated control. At the end of the experimental period oxidative
stress indices viz. lipid peroxides level (LPO), superoxide dismutase (SOD) and catalase (CAT) activities were
estimated in blood, liver and kidneys from sacrificed rats. Arsenic exposure resulted in a significant (P<0.05)
rise in LPO levels and activities of SOD and CAT in erythrocytes, liver and kidneys. All the different treatments
reduced lipid peroxides levels and restored activities of antioxidant enzymes to variable extents in various
tissues. However, arsenic exposure did not show any significant (P>0.05) effects on the body mass of rats
of different groups over time. It is concluded from the present study that prophylactic co-administration of
cysteine, methionine and ascorbic acid could provide tissue specific protection from oxidative injury during
sub-chronic exposure to arsenic.
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Veterinarski Arhiv 78 (2), 113-121, 2008